Summary of IL2
The IL2 gene encodes interleukin-2, an important inflammatory messenger [R].
IL-2 stimulates the proliferation of T and B cells. It interacts with many other interleukins, including IL-4, IL-7, IL-9, IL-15, and IL-21. IL-2 is essential for a healthy immune response. It increases cytokine and antibody production. It also promotes programmed cell death [R, R, R].
IL-2 helps maintain homeostasis in the immune system. An imbalance in IL-2 or its receptor may contribute to autoimmunity [R].
Variants in IL2 have been linked to [R, R, R, R]:
- Cytokine concentration
- Celiac disease
- Type 1 diabetes
- Autoimmune disease
Protein names
Recommended name:
Interleukin-2Short name:
IL-2Alternative name(s):
T-cell growth factorTCGF
Aldesleukin
- RS148505069 (IL2) ??
- RS17388568 (IL2) ??
- RS17389644 (IL2) ??
- RS17454584 (IL2) ??
- RS1880242 (IL2) ??
- RS2069762 (IL2) ??
- RS2069763 (IL2) ??
- RS2069772 (IL2) ??
- RS45475795 (IL2) ??
- RS6822844 (IL2) ??
- RS6852535 (IL2) ??
- RS7682241 (IL2) ??
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Top Gene-Substance Interactions
IL2 Interacts with These Diseases
| Disease | Score |
Fixes
Substances That Increase IL2
| Substances | Interaction | Organism | Category |
Substances That Decrease IL2
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: rheumatoid arthritisFrom UniProt: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
From NCBI Gene: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] From UniProt: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Immune System
- Cytokine-cytokine receptor interaction
- Chagas disease (American trypanosomiasis)
- Intestinal immune network for IgA production
- Allograft rejection
- T cell receptor signaling pathway
- Type I diabetes mellitus
- Graft-versus-host disease
- Autoimmune thyroid disease
- Measles
- Jak-STAT signaling pathway
Molecular Function:
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Cytokine Activity
- Interleukin-2 Receptor Binding
- Growth Factor Activity
- Kinase Activator Activity
- Carbohydrate Binding
- Glycosphingolipid Binding
Biological Processes:
- Mapk Cascade
- Negative Regulation Of Protein Phosphorylation
- Adaptive Immune Response
- Negative Regulation Of B Cell Apoptotic Process
- Immune Response
- Cell Adhesion
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Protein Kinase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Cell-Cell Signaling
- Positive Regulation Of Cell Proliferation
- Natural Killer Cell Activation
- T Cell Differentiation
- Positive Regulation Of Cell Growth
- Positive Regulation Of B Cell Proliferation
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-17 Production
- Positive Regulation Of Tissue Remodeling
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Negative Regulation Of Apoptotic Process
- Response To Ethanol
- Positive Regulation Of Regulatory T Cell Differentiation
- Negative Regulation Of Heart Contraction
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of T Cell Homeostatic Proliferation
- Positive Regulation Of Isotype Switching To Igg Isotypes
- Negative Regulation Of Lymphocyte Proliferation
- Negative Regulation Of Inflammatory Response
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Immunoglobulin Secretion
- Positive Regulation Of Dendritic Spine Development
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand