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  3. IL2

IL2 (Interleukin 2)

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Summary of IL2

The gene codes for a protein, interleukin 2. It plays a role in the proliferation of T and B lymphocytes [R].

It's better to have this gene decreased most of the time.
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The Function of IL2

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Protein names

Recommended name:

Interleukin-2

Short name:

IL-2

Alternative name(s):

T-cell growth factor
TCGF
Aldesleukin

IL2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS148505069 (IL2) ??
  2. RS17388568 (IL2) ??
  3. RS17389644 (IL2) ??
  4. RS17454584 (IL2) ??
  5. RS1880242 (IL2) ??
  6. RS2069762 (IL2) ??
  7. RS2069763 (IL2) ??
  8. RS2069772 (IL2) ??
  9. RS45475795 (IL2) ??
  10. RS6822844 (IL2) ??
  11. RS6852535 (IL2) ??
  12. RS7682241 (IL2) ??

Top Gene-Substance Interactions

IL2 Interacts with These Diseases

Disease Score

Fixes

Read: How To Rebalance An Elevated Th1 Immune System

Substances That Increase IL2

Substances Interaction Organism Category

Substances That Decrease IL2

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: rheumatoid arthritisFrom UniProt: A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

     From NCBI Gene: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008] From UniProt: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • AP-1
  • c-Jun
  • NF-kappaB1
  • AML1a
  • c-Rel
  • NF-AT2

Gene Pathways:

  • Immune System
  • Cytokine-cytokine receptor interaction
  • Chagas disease (American trypanosomiasis)
  • Intestinal immune network for IgA production
  • Allograft rejection
  • T cell receptor signaling pathway
  • Type I diabetes mellitus
  • Graft-versus-host disease
  • Autoimmune thyroid disease
  • Measles
  • Jak-STAT signaling pathway

Molecular Function:

  • Carbohydrate Binding
  • Cytokine Activity
  • Glycosphingolipid Binding
  • Growth Factor Activity
  • Interleukin-2 Receptor Binding
  • Kinase Activator Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Adaptive Immune Response
  • Cell Adhesion
  • Cell-Cell Signaling
  • Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
  • Immune Response
  • Mapk Cascade
  • Natural Killer Cell Activation
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of B Cell Apoptotic Process
  • Negative Regulation Of Heart Contraction
  • Negative Regulation Of Inflammatory Response
  • Negative Regulation Of Lymphocyte Proliferation
  • Negative Regulation Of Protein Phosphorylation
  • Positive Regulation Of Activated T Cell Proliferation
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Cell Growth
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Dendritic Spine Development
  • Positive Regulation Of Immunoglobulin Secretion
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Interleukin-17 Production
  • Positive Regulation Of Isotype Switching To Igg Isotypes
  • Positive Regulation Of Regulatory T Cell Differentiation
  • Positive Regulation Of Tissue Remodeling
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
  • Protein Kinase C-Activating G-Protein Coupled Receptor Signaling Pathway
  • Regulation Of T Cell Homeostatic Proliferation
  • Response To Ethanol
  • T Cell Differentiation

Drug Bank:

  • Apremilast
  • Pseudoephedrine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

aldesleukin| GW7_11784| H920_01827| IL-2| interleukin2| interleukin-2| interleukin-2-like protein| interleukin-2 precursor protein| involved in regulation of T-cell clonal expansion| lymphokine| MDA_GLEAN10021189| PAL_GLEAN10013937| PANDA_013093| patial sequence of Interleukin-2| POIL2| T cell growth factor| T-cell growth factor| TCGF| TREES_T100015041| il2

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