Summary of HSD3B1
The gene codes for a protein, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. It aids with the production of all classes of steroid hormones [R].
The Function of HSD3B1
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.
Protein names
Recommended name:
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1Short name:
5Alternative name(s):
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I3-beta-HSD I
Trophoblast antigen FDO161G
3-beta-hydroxy-5-ene steroid dehydrogenase
Progesterone reductase
Delta-5-3-ketosteroid isomerase
- RS3765945 (HSD3B1) ??
- RS6203 (HSD3B1) ??
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Top Gene-Substance Interactions
HSD3B1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HSD3B1
| Substances | Interaction | Organism | Category |
Substances That Decrease HSD3B1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Placenta and skin. Predominantly expressed in mammary gland tissue.
Gene Pathways:
Molecular Function:
Biological Processes:
- Steroid Biosynthetic Process
- Androgen Biosynthetic Process
- Estrogen Biosynthetic Process
- Glucocorticoid Biosynthetic Process
- Mineralocorticoid Biosynthetic Process