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HSD3B1 (Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1)

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Summary of HSD3B1

The gene codes for a protein, hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. It aids with the production of all classes of steroid hormones [R].

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The Function of HSD3B1

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.

Protein names

Recommended name:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

Short name:

5

Alternative name(s):

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
3-beta-HSD I
Trophoblast antigen FDO161G
3-beta-hydroxy-5-ene steroid dehydrogenase
Progesterone reductase
Delta-5-3-ketosteroid isomerase

HSD3B1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3765945 (HSD3B1) ??
  2. RS6203 (HSD3B1) ??

Top Gene-Substance Interactions

HSD3B1 Interacts with These Diseases

Disease Score

Substances That Increase HSD3B1

Substances Interaction Organism Category

Substances That Decrease HSD3B1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • YY1

Tissue specificity:

Placenta and skin. Predominantly expressed in mammary gland tissue.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Steroid hormones

Molecular Function:

  • 3-Beta-Hydroxy-Delta5-Steroid Dehydrogenase Activity
  • Steroid Delta-Isomerase Activity

Biological Processes:

  • Androgen Biosynthetic Process
  • Estrogen Biosynthetic Process
  • Glucocorticoid Biosynthetic Process
  • Mineralocorticoid Biosynthetic Process
  • Steroid Biosynthetic Process

Drug Bank:

  • Trilostane
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| I| 3-beta-HSD I| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I| 3 beta-HSD| 3-beta-HSD| 3BETAHSD| 3-beta-hydroxy-5-ene steroid dehydrogenase| 3-beta-hydroxy-Delta(5)-steroid dehydrogenase| 3 beta-hydroxysteroid dehydrogenase| 3-beta-hydroxysteroid dehydrogenase| 3 beta-hydroxysteroid dehydrogenase 1| 3-beta-hydroxysteroid dehydrogenase 1| 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase| 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase| 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase| 3beta-hydroxysteroid dehydrogenase/isomerase| 3BHSD| 3B-HSD| D3Ertd383e| delta-5-3-ketosteroid isomerase| delta 5-4-isomerase| HSD3B| HSDB3| HSDB3A| hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase| hydroxysteroid dehydrogenase-1, delta<5>-3-beta| PANDA_018384| progesterone reductase| SDR11E1| short chain dehydrogenase/reductase family 11E, member 1| steroid Delta-isomerase| trophoblast antigen FDO161G| hsd3b1

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