Summary of HRH2
The Function of HRH2
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway.
Protein names
Recommended name:
Histamine H2 receptorShort name:
H2RAlternative name(s):
HH2RGastric receptor I
- RS10039217 (HRH2) ??
- RS10476160 (HRH2) ??
- RS1707420 (HRH2) ??
- RS2067474 (HRH2) ??
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Top Gene-Substance Interactions
HRH2 Interacts with These Diseases
| Disease | Score |
Substances That Increase HRH2
| Substances | Interaction | Organism | Category |
Substances That Decrease HRH2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Histamine-Induced Gastric Acid Secretion
- Gastrin-Induced Gastric Acid Secretion
- Epithelial Cell Morphogenesis
- Immune Response
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Memory
- Visual Learning
- Positive Regulation Of Vasoconstriction
- Regulation Of Synaptic Plasticity
- Digestive Tract Development
- Gland Development
- Toxin Transport
Drug Bank:
- Asenapine
- Betazole
- Cimetidine
- Epinastine
- Famotidine
- Histamine Phosphate
- Loxapine
- Nizatidine
- Olanzapine
- Ranitidine
- Roxatidine Acetate
- Amitriptyline
- Doxepin
- Methantheline
- Tolazoline