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  3. HRH2

HRH2 (Histamine receptor H2)

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Summary of HRH2

The gene codes for a protein, histamine receptor H2. It stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion. It also may regulate cell growth and differentiation [R].

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The Function of HRH2

The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway.

Protein names

Recommended name:

Histamine H2 receptor

Short name:

H2R

Alternative name(s):

HH2R
Gastric receptor I

HRH2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10039217 (HRH2) ??
  2. RS10476160 (HRH2) ??
  3. RS1707420 (HRH2) ??
  4. RS2067474 (HRH2) ??

Top Gene-Substance Interactions

HRH2 Interacts with These Diseases

Disease Score

Substances That Increase HRH2

Substances Interaction Organism Category

Substances That Decrease HRH2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • PPAR-alpha
  • Meis-1
  • E47
  • Meis-1b

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway
  • Gastric acid secretion

Molecular Function:

  • Histamine Receptor Activity

Biological Processes:

  • Digestive Tract Development
  • Epithelial Cell Morphogenesis
  • Gastrin-Induced Gastric Acid Secretion
  • Gland Development
  • G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
  • Histamine-Induced Gastric Acid Secretion
  • Immune Response
  • Memory
  • Positive Regulation Of Vasoconstriction
  • Regulation Of Synaptic Plasticity
  • Toxin Transport
  • Visual Learning

Drug Bank:

  • Asenapine
  • Betazole
  • Cimetidine
  • Epinastine
  • Famotidine
  • Histamine Phosphate
  • Loxapine
  • Nizatidine
  • Olanzapine
  • Ranitidine
  • Roxatidine Acetate
  • Amitriptyline
  • Doxepin
  • Methantheline
  • Tolazoline
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_18983| AS27_11955| AS28_10594| CB1_000672024| D623_10024171| gastric receptor 1| gastric receptor I| H2R| H920_04432| HH2R| histamine H2 receptor| Histamine H2 receptor-like protein| histamine receptor H 2| histamine receptor subtype H2| M91_13126| M959_08374| MDA_GLEAN10021418| N300_12988| N301_00613| N302_05304| N303_03111| N307_13740| N310_05865| N311_03108| N312_06311| N320_04884| N321_05250| N324_08599| N325_07884| N326_09684| N327_00857| N329_03143| N333_13583| N335_07936| N339_02358| N341_05066| PAL_GLEAN10018920| PANDA_010689| TREES_T100010107| UY3_11952| Y1Q_016785| Y956_04273| hrh2

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