Summary of HIF1A
HIF1A encodes HIF which regulates responses to hypoxia by activating transcription of genes that cause the development of blood vessels, cell death, energy metabolism, etc. (R).
Overexpression of HIF1A can cause cancer and tumor progression (R).
The Function of HIF1A
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Protein names
Recommended name:
Hypoxia-inducible factor 1-alphaAlternative name(s):
HIF-1-alphaHIF1-alpha
ARNT-interacting protein
Basic-helix-loop-helix-PAS protein MOP1
Class E basic helix-loop-helix protein 78
bHLHe78
Member of PAS protein 1
PAS domain-containing protein 8
- RS11549465 (HIF1A) ??
- RS11549467 (HIF1A) ??
- RS12434438 (HIF1A) ??
- RS1951795 (HIF1A) ??
- RS1957757 (HIF1A) ??
- RS2301113 (HIF1A) ??
- RS8005745 (HIF1A) ??
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Top Gene-Substance Interactions
HIF1A Interacts with These Diseases
| Disease | Score |
Fixes
Methods to Increase HIF1A levels:
- Increased levels of Triiodothyronine [R].
Substances That Increase HIF1A
| Substances | Interaction | Organism | Category |
Substances That Decrease HIF1A
| Substances | Interaction | Organism | Category |
Advanced Summary
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
Gene Pathways:
Induction:
Under reduced oxygen tension. Induced also by various receptor-mediated factors such as growth factors, cytokines, and circulatory factors such as PDGF, EGF, FGF2, IGF2, TGFB1, HGF, TNF, IL1B/interleukin-1 beta, angiotensin-2 and thrombin. However, this induction is less intense than that stimulated by hypoxia. Repressed by HIPK2 and LIMD1.
Molecular Function:
- Transcription Factor Activity, Transcription Factor Binding
- Transcription Factor Activity, Rna Polymerase Ii Transcription Factor Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Binding
- Enzyme Binding
- Protein Kinase Binding
- Ubiquitin Protein Ligase Binding
- Histone Acetyltransferase Binding
- Nuclear Hormone Receptor Binding
- Sequence-Specific Dna Binding
- Protein Heterodimerization Activity
- Hsp90 Protein Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Angiogenesis
- Response To Hypoxia
- Neural Crest Cell Migration
- Epithelial To Mesenchymal Transition
- Embryonic Placenta Development
- B-1 B Cell Homeostasis
- Positive Regulation Of Endothelial Cell Proliferation
- Heart Looping
- Positive Regulation Of Neuroblast Proliferation
- Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
- Outflow Tract Morphogenesis
- Cardiac Ventricle Morphogenesis
- Lactate Metabolic Process
- Regulation Of Transcription, Dna-Templated
- Transcription From Rna Polymerase Ii Promoter
- Cellular Iron Ion Homeostasis
- Acute-Phase Response
- Signal Transduction
- Lactation
- Visual Learning
- Response To Salt Stress
- Response To X-Ray
- Regulation Of Gene Expression
- Vascular Endothelial Growth Factor Production
- Positive Regulation Of Vascular Endothelial Growth Factor Production
- Positive Regulation Of Gene Expression
- Positive Regulation Of Epithelial Cell Migration
- Positive Regulation Of Receptor Biosynthetic Process
- Response To Auditory Stimulus
- Response To Purine-Containing Compound
- Response To Muscle Activity
- Positive Regulation Of Macroautophagy
- Axonal Transport Of Mitochondrion
- Neural Fold Elevation Formation
- Cerebral Cortex Development
- Negative Regulation Of Bone Mineralization
- Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Tor Signaling
- Response To Estradiol
- Oxygen Homeostasis
- Positive Regulation Of Chemokine Production
- Cellular Response To Insulin Stimulus
- Regulation Of Transforming Growth Factor Beta2 Production
- Collagen Metabolic Process
- Embryonic Hemopoiesis
- Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
- Hemoglobin Biosynthetic Process
- Glucose Homeostasis
- Mrna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Apoptotic Process
- Response To Alkaloid
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Oxidative Stress
- Response To Estrogen
- Positive Regulation Of Erythrocyte Differentiation
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Cell Size
- Positive Regulation Of Glycolytic Process
- Positive Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Vasoconstriction
- Negative Regulation Of Growth
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Muscle Cell Cellular Homeostasis
- Positive Regulation Of Hormone Biosynthetic Process
- Digestive Tract Morphogenesis
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Nitric-Oxide Synthase Activity
- Cartilage Development
- Response To Glucocorticoid
- Elastin Metabolic Process
- Maternal Process Involved In Female Pregnancy
- Intestinal Epithelial Cell Maturation
- Response To Fungicide
- Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
- Iris Morphogenesis
- Retina Vasculature Development In Camera-Type Eye
- Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia
- Positive Regulation Of Chemokine-Mediated Signaling Pathway
- Negative Regulation Of Thymocyte Apoptotic Process
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Lipopolysaccharide
- Cellular Response To Carbon Monoxide
- Cellular Response To Nitrite
- Cellular Response To Electrical Stimulus
- Cellular Response To Mechanical Stimulus
- Cellular Response To Cobalt Ion
- Cellular Response To Glucose Stimulus
- Cellular Response To Interleukin-1
- Cellular Response To Organic Cyclic Compound
- Cellular Response To Hypoxia
- Cellular Response To Light Stimulus
- Dopaminergic Neuron Differentiation
- Response To Anesthetic
- Cellular Response To Toxic Substance
- Hypoxia-Inducible Factor-1alpha Signaling Pathway
- Regulation Of Cellular Response To Hypoxia
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Oxidative Stress-Induced Neuron Intrinsic Apoptotic Signaling Pathway
- Positive Regulation Of Mitophagy
- Regulation Of Aerobic Respiration
- Cellular Response To Cyanide
- Negative Regulation Of Reactive Oxygen Species Metabolic Process
- Negative Regulation Of Mesenchymal Cell Apoptotic Process