Summary of HDAC4
This gene encodes a protein that helps regulate gene transcription and cell cycle progress. Mutations can cause developmental problems (R).
The Function of HDAC4
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Protein names
Recommended name:
Histone deacetylase 4Short name:
HD4- RS10200850 (HDAC4) ??
- RS12477314 (HDAC4) ??
- RS3791556 (HDAC4) ??
- RS62191099 (HDAC4) ??
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Top Gene-Substance Interactions
HDAC4 Interacts with These Diseases
| Disease | Score |
Substances That Increase HDAC4
| Substances | Interaction | Organism | Category |
Substances That Decrease HDAC4
| Substances | Interaction | Organism | Category |
Advanced Summary
From UniProt: Brachydactyly-mental retardation syndrome (BDMR): A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. [MIM:600430]
From NCBI Gene: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] From UniProt: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer .
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Gene Pathways:
Molecular Function:
- Rna Polymerase Iii Transcription Factor Binding
- Core Promoter Binding
- Chromatin Binding
- Transcription Corepressor Activity
- Histone Deacetylase Activity
- Transcription Factor Binding
- Zinc Ion Binding
- Potassium Ion Binding
- Nad-Dependent Histone Deacetylase Activity (H3-K14 Specific)
- Protein Deacetylase Activity
- Activating Transcription Factor Binding
- Histone Deacetylase Binding
- Repressing Transcription Factor Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Skeletal System Development
- Osteoblast Development
- Chromatin Remodeling
- Transcription, Dna-Templated
- Inflammatory Response
- Nervous System Development
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Positive Regulation Of Lamellipodium Assembly
- Negative Regulation Of Myotube Differentiation
- Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
- Response To Denervation Involved In Regulation Of Muscle Adaptation
- Cardiac Muscle Hypertrophy In Response To Stress
- Positive Regulation Of Smooth Muscle Cell Migration
- Histone Deacetylation
- B Cell Differentiation
- Positive Regulation Of Protein Sumoylation
- Peptidyl-Lysine Deacetylation
- Regulation Of Gene Expression, Epigenetic
- B Cell Activation
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of Neuron Apoptotic Process
- Negative Regulation Of Osteoblast Differentiation
- Negative Regulation Of Glycolytic Process
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Regulation Of Skeletal Muscle Fiber Development
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Response To Interleukin-1
- Histone H3 Deacetylation
- Histone H4 Deacetylation
- Cellular Response To Mechanical Stimulus
- Cellular Response To Tumor Necrosis Factor
- Cellular Response To Parathyroid Hormone Stimulus
- Positive Regulation Of Reactive Oxygen Species Biosynthetic Process