Summary of HDAC4
This gene encodes a protein that helps regulate gene transcription and cell cycle progress. Mutations can cause developmental problems (R).
The Function of HDAC4
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Protein names
Recommended name:
Histone deacetylase 4Short name:
HD4- RS10200850 (HDAC4) ??
- RS12477314 (HDAC4) ??
- RS3791556 (HDAC4) ??
- RS62191099 (HDAC4) ??
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Top Gene-Substance Interactions
HDAC4 Interacts with These Diseases
| Disease | Score |
Substances That Increase HDAC4
| Substances | Interaction | Organism | Category |
Substances That Decrease HDAC4
| Substances | Interaction | Organism | Category |
Advanced Summary
From UniProt: Brachydactyly-mental retardation syndrome (BDMR): A syndrome resembling the physical anomalies found in Albright hereditary osteodystrophy. Common features are mild facial dysmorphism, congenital heart defects, distinct brachydactyly type E, mental retardation, developmental delay, seizures, autism spectrum disorder, and stocky build. Soft tissue ossification is absent, and there are no abnormalities in parathyroid hormone or calcium metabolism. [MIM:600430]
From NCBI Gene: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] From UniProt: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer .
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitous.
Gene Pathways:
Molecular Function:
- Activating Transcription Factor Binding
- Chromatin Binding
- Core Promoter Binding
- Histone Deacetylase Activity
- Histone Deacetylase Binding
- Nad-Dependent Histone Deacetylase Activity (H3-K14 Specific)
- Potassium Ion Binding
- Protein Deacetylase Activity
- Repressing Transcription Factor Binding
- Rna Polymerase Iii Transcription Factor Binding
- Transcription Corepressor Activity
- Transcription Factor Binding
- Zinc Ion Binding
Biological Processes:
- B Cell Activation
- B Cell Differentiation
- Cardiac Muscle Hypertrophy In Response To Stress
- Cellular Response To Mechanical Stimulus
- Cellular Response To Parathyroid Hormone Stimulus
- Cellular Response To Tumor Necrosis Factor
- Chromatin Remodeling
- Histone Deacetylation
- Histone H3 Deacetylation
- Histone H4 Deacetylation
- Inflammatory Response
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Glycolytic Process
- Negative Regulation Of Myotube Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Nervous System Development
- Osteoblast Development
- Peptidyl-Lysine Deacetylation
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Lamellipodium Assembly
- Positive Regulation Of Neuron Apoptotic Process
- Positive Regulation Of Protein Sumoylation
- Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of Smooth Muscle Cell Migration
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
- Regulation Of Gene Expression, Epigenetic
- Regulation Of Skeletal Muscle Fiber Development
- Response To Denervation Involved In Regulation Of Muscle Adaptation
- Response To Interleukin-1
- Skeletal System Development
- Transcription, Dna-Templated