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  3. GSTM1

GSTM1 (Glutathione S-transferase mu 1)

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Summary of GSTM1

GSTM1 is a mu class glutathione S-transferase . The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione .

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The Function of GSTM1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Protein names

Recommended name:

Glutathione S-transferase Mu 1

Short name:

GTH4

Alternative name(s):

GST HB subunit 4
GST class-mu 1
GSTM1-1
GSTM1a-1a
GSTM1b-1b

Top Gene-Substance Interactions

GSTM1 Interacts with These Diseases

Disease Score

Substances That Increase GSTM1

Substances Interaction Organism Category

Substances That Decrease GSTM1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • p53
  • Max
  • TBP
  • TFIID
  • c-Myb

Tissue specificity:

Liver (at protein level).

Gene Pathways:

  • Metabolism
  • Glutathione metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Drug metabolism - cytochrome P450

Molecular Function:

  • Enzyme Binding
  • Glutathione Binding
  • Glutathione Transferase Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Cellular Detoxification Of Nitrogen Compound
  • Glutathione Derivative Biosynthetic Process
  • Glutathione Metabolic Process
  • Nitrobenzene Metabolic Process
  • Xenobiotic Catabolic Process

Drug Bank:

  • Busulfan
  • Carboplatin
  • Cisplatin
  • Glutathione
  • Azathioprine
  • Oxaliplatin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| gst1| Gst-1| GST 1-1| GSTA3| glutathione S-alkyltransferase| glutathione S-aralkyltransferase| glutathione S-aryltransferase| Glutathione S-transferase 1| Glutathione S-transferase 4| glutathione S-transferase GT8.7| glutathione S-transferase M1| glutathione S-transferase, mu 1| glutathione-S-transferase, mu type 1 (Yb1)| glutathione S-transferase Yb-1 subunit| glutathione transferase I| glutatione transferase-4| GST 3-3| Gst4| Gst-4| Gstb1| Gstb-1| GST class-mu 1| GST class-theta| GST HB subunit 4| GSTM1-1| GSTM1a-1a| GSTM1b-1b| gst-mu| GST Yb1| gth4| GTM1| H-B| HB subunit 4| MU| MU-1| pmGT10| S-(hydroxyalkyl)glutathione lyase| gstm1

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