Summary of GSTM1
GSTM1 is a mu class glutathione S-transferase . The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione .
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The Function of GSTM1
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Protein names
Recommended name:
Glutathione S-transferase Mu 1Short name:
GTH4Alternative name(s):
GST HB subunit 4GST class-mu 1
GSTM1-1
GSTM1a-1a
GSTM1b-1b
Top Gene-Substance Interactions
GSTM1 Interacts with These Diseases
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Substances That Increase GSTM1
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Substances That Decrease GSTM1
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver (at protein level).
Gene Pathways:
Molecular Function:
- Enzyme Binding
- Glutathione Binding
- Glutathione Transferase Activity
- Protein Homodimerization Activity
Biological Processes:
- Cellular Detoxification Of Nitrogen Compound
- Glutathione Derivative Biosynthetic Process
- Glutathione Metabolic Process
- Nitrobenzene Metabolic Process
- Xenobiotic Catabolic Process