Summary of GSTM1
GSTM1 is a mu class glutathione S-transferase . The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione .
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The Function of GSTM1
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Protein names
Recommended name:
Glutathione S-transferase Mu 1Short name:
GTH4Alternative name(s):
GST HB subunit 4GST class-mu 1
GSTM1-1
GSTM1a-1a
GSTM1b-1b
Top Gene-Substance Interactions
GSTM1 Interacts with These Diseases
| Disease | Score |
Substances That Increase GSTM1
| Substances | Interaction | Organism | Category |
Substances That Decrease GSTM1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver (at protein level).
Gene Pathways:
Molecular Function:
- Glutathione Transferase Activity
- Enzyme Binding
- Protein Homodimerization Activity
- Glutathione Binding
Biological Processes:
- Glutathione Metabolic Process
- Nitrobenzene Metabolic Process
- Xenobiotic Catabolic Process
- Cellular Detoxification Of Nitrogen Compound
- Glutathione Derivative Biosynthetic Process