Summary of FYN
This gene encodes a protein that helps with cell growth (R).
The Function of FYN
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Protein names
Recommended name:
Tyrosine-protein kinase FynShort name:
SLKAlternative name(s):
Proto-oncogene SynProto-oncogene c-Fyn
Src-like kinase
p59-Fyn
- RS2148710 (FYN) ??
- RS706895 (FYN) ??
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Top Gene-Substance Interactions
FYN Interacts with These Diseases
| Disease | Score |
Substances That Increase FYN
| Substances | Interaction | Organism | Category |
Substances That Decrease FYN
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
Gene Pathways:
- Disease
- Immune System
- Signal Transduction
- Hemostasis
- Measles
- Natural killer cell mediated cytotoxicity
- Adherens junction
- Cell-Cell communication
- Pathogenic Escherichia coli infection
- Axon guidance
- T cell receptor signaling pathway
- Osteoclast differentiation
- Prion diseases
- Fc epsilon RI signaling pathway
- Viral myocarditis
Enzyme Regulation:
Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
Molecular Function:
- Glycoprotein Binding
- Protein Tyrosine Kinase Activity
- Non-Membrane Spanning Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Atp Binding
- Metal Ion Binding
- Ephrin Receptor Binding
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Growth Factor Receptor Binding
Biological Processes:
- Mapk Cascade
- Neuron Migration
- Stimulatory C-Type Lectin Receptor Signaling Pathway
- Adaptive Immune Response
- Protein Phosphorylation
- Calcium Ion Transport
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
- Axon Guidance
- Central Nervous System Development
- Blood Coagulation
- Learning
- Feeding Behavior
- Regulation Of Cell Shape
- Negative Regulation Of Gene Expression
- Positive Regulation Of Neuron Projection Development
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Viral Process
- Peptidyl-Tyrosine Phosphorylation
- Cell Differentiation
- Platelet Activation
- Forebrain Development
- T Cell Costimulation
- Negative Regulation Of Protein Ubiquitination
- Intracellular Signal Transduction
- Cellular Response To Platelet-Derived Growth Factor Stimulus
- Peptidyl-Tyrosine Autophosphorylation
- Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
- T Cell Activation
- Regulation Of Cell Proliferation
- Negative Regulation Of Protein Catabolic Process
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Regulation Of Apoptotic Process
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Negative Regulation Of Neuron Apoptotic Process
- Innate Immune Response
- Response To Ethanol
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Ephrin Receptor Signaling Pathway
- Phosphatidylinositol-Mediated Signaling
- Dendrite Morphogenesis
- Regulation Of Defense Response To Virus By Virus
- Activated T Cell Proliferation
- T Cell Receptor Signaling Pathway
- Leukocyte Migration
- Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
- Cellular Response To Peptide Hormone Stimulus
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Positive Regulation Of Protein Localization To Nucleus
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand