Summary of FYN
This gene encodes a protein that helps with cell growth (R).
The Function of FYN
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Protein names
Recommended name:
Tyrosine-protein kinase FynShort name:
SLKAlternative name(s):
Proto-oncogene SynProto-oncogene c-Fyn
Src-like kinase
p59-Fyn
- RS2148710 (FYN) ??
- RS706895 (FYN) ??
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Top Gene-Substance Interactions
FYN Interacts with These Diseases
| Disease | Score |
Substances That Increase FYN
| Substances | Interaction | Organism | Category |
Substances That Decrease FYN
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
Gene Pathways:
- Disease
- Immune System
- Signal Transduction
- Hemostasis
- Measles
- Natural killer cell mediated cytotoxicity
- Adherens junction
- Cell-Cell communication
- Pathogenic Escherichia coli infection
- Axon guidance
- T cell receptor signaling pathway
- Osteoclast differentiation
- Prion diseases
- Fc epsilon RI signaling pathway
- Viral myocarditis
Enzyme Regulation:
Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
Molecular Function:
- Atp Binding
- Ephrin Receptor Binding
- Glycoprotein Binding
- Growth Factor Receptor Binding
- Metal Ion Binding
- Non-Membrane Spanning Protein Tyrosine Kinase Activity
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
Biological Processes:
- Activated T Cell Proliferation
- Adaptive Immune Response
- Axon Guidance
- Blood Coagulation
- Calcium Ion Transport
- Cell Differentiation
- Cellular Response To Peptide Hormone Stimulus
- Cellular Response To Platelet-Derived Growth Factor Stimulus
- Cellular Response To Transforming Growth Factor Beta Stimulus
- Central Nervous System Development
- Dendrite Morphogenesis
- Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
- Ephrin Receptor Signaling Pathway
- Fc-Gamma Receptor Signaling Pathway Involved In Phagocytosis
- Feeding Behavior
- Forebrain Development
- Innate Immune Response
- Intracellular Signal Transduction
- Learning
- Leukocyte Migration
- Mapk Cascade
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Negative Regulation Of Gene Expression
- Negative Regulation Of Neuron Apoptotic Process
- Negative Regulation Of Protein Catabolic Process
- Negative Regulation Of Protein Ubiquitination
- Neuron Migration
- Peptidyl-Tyrosine Autophosphorylation
- Peptidyl-Tyrosine Phosphorylation
- Phosphatidylinositol-Mediated Signaling
- Platelet Activation
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Neuron Projection Development
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Protein Localization To Nucleus
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Protein Phosphorylation
- Regulation Of Apoptotic Process
- Regulation Of Cell Proliferation
- Regulation Of Cell Shape
- Regulation Of Defense Response To Virus By Virus
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Response To Ethanol
- Stimulatory C-Type Lectin Receptor Signaling Pathway
- T Cell Activation
- T Cell Costimulation
- T Cell Receptor Signaling Pathway
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
- Vascular Endothelial Growth Factor Receptor Signaling Pathway
- Viral Process