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  3. CHRNA5

CHRNA5 (Cholinergic receptor nicotinic alpha 5 subunit)

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Summary of CHRNA5

The CHRNA5 gene produces a component of nicotinic receptors. Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of receptors that can mediate fast signal transmission at synapses (R), as well as increase the release of several neurotransmitters (R). Nicotine activates these receptors. 

Higher CHRNA5 gene production results in more 5 subunit production and therefore more nictoine dependence risk (R). Lower CHRNA5 gene production results in lower 5 subunit production.

 Inclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization (R), which increases nicotine dependence risk.

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The Function of CHRNA5

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Protein names

Recommended name:

Neuronal acetylcholine receptor subunit alpha-5

CHRNA5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS16969968 (CHRNA5) ??
  2. RS17486278 (CHRNA5) ??
  3. RS2036527 (CHRNA5) ??
  4. RS503464 (CHRNA5) ??
  5. RS569207 (CHRNA5) ??
  6. RS588765 (CHRNA5) ??
  7. RS6495306 (CHRNA5) ??
  8. RS667282 (CHRNA5) ??
  9. RS680244 (CHRNA5) ??

Top Gene-Substance Interactions

CHRNA5 Interacts with These Diseases

Disease Score

Fixes

Do not start smoking or nicotine.

Substances That Increase CHRNA5

Substances Interaction Organism Category

Substances That Decrease CHRNA5

Substances Interaction Organism Category

Advanced Summary

The CHRNA5 gene produces a component of nicotinic receptors. Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of receptors that can mediate fast signal transmission at synapses (R), as well as increase the release of several neurotransmitters (R).

Nicotine activates these receptors. The most abundant receptor variation in the brain is the 4²2 subtype. Some 4²2 receptors also contain an 5 subunit (R). I

nclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization and calcium permeability (R). Higher CHRNA5 gene production results in more 5 subunit production and therefore more nictoine dependence risk (R).

Lower CHRNA5 gene production results in lower 5 subunit production.  Inclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization (R), which increases nicotine dependence risk.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • MEF-2A
  • GATA-1
  • E4BP4
  • GATA-2
  • GATA-3
  • HFH-1

Gene Pathways:

  • Neuroactive ligand-receptor interaction
  • Neuronal System

Molecular Function:

  • Acetylcholine-Activated Cation-Selective Channel Activity
  • Acetylcholine Receptor Activity
  • Ligand-Gated Ion Channel Activity
  • Acetylcholine Binding

Biological Processes:

  • Behavioral Response To Nicotine
  • Chemical Synaptic Transmission
  • Neuromuscular Synaptic Transmission
  • Signal Transduction
  • Synaptic Transmission, Cholinergic
  • Transport

Drug Bank:

  • Ethanol
  • Nicotine
  • Galantamine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| LNCR2| A306_02591| acetylcholine receptor alpha 5| acetylcholine receptor, nicotinic, alpha 5 (neuronal)| Acra5| Acra-5| AS27_06165| AS28_07315| CB1_000113006| Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5| cholinergic receptor neuronal nicotinic alpha protein 5| cholinergic receptor, nicotinic alpha 5| cholinergic receptor, nicotinic, alpha 5| cholinergic receptor, nicotinic, alpha 5 (neuronal)| cholinergic receptor, nicotinic, alpha polypeptide 5| D623_10007158| frb7| GW7_10860| H920_03296| I79_003578| M959_05210| MDA_GLEAN10005734| N300_12558| N301_08908| N302_08485| N303_01396| N305_01343| N306_15263| N307_11155| N308_02833| N309_07109| N310_07089| N311_00289| N312_01211| N320_06939| N321_00293| N322_10684| N324_12981| N325_12350| N327_02231| N329_11230| N330_00165| N331_05758| N332_11011| N333_07584| N334_09455| N335_12588| N336_10045| N339_00122| N340_06113| N341_09637| Neuronal acetylcholine receptor subunit alpha-5| neuronal acetylcholine receptor subunit alpha-5-like protein| neuronal nicotinic acetylcholine receptor, alpha5 subunit| nica5| nicotinic acetylcholine receptor alpha5 subunit| nicotinic acetylcholine receptor beta 7 subunit| nicotinic acetylcholine receptor subunit alpha5| PAL_GLEAN10009619| PANDA_012137| TREES_T100016661| UY3_15140| Y1Q_016341| Y956_05505| Z169_06574| chrna5

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