Summary of CHRNA5
The CHRNA5 gene produces a component of nicotinic receptors. Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of receptors that can mediate fast signal transmission at synapses (R), as well as increase the release of several neurotransmitters (R). Nicotine activates these receptors.
Higher CHRNA5 gene production results in more 5 subunit production and therefore more nictoine dependence risk (R). Lower CHRNA5 gene production results in lower 5 subunit production.
Inclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization (R), which increases nicotine dependence risk.
The Function of CHRNA5
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Protein names
Recommended name:
Neuronal acetylcholine receptor subunit alpha-5- RS16969968 (CHRNA5) ??
- RS17486278 (CHRNA5) ??
- RS2036527 (CHRNA5) ??
- RS503464 (CHRNA5) ??
- RS569207 (CHRNA5) ??
- RS588765 (CHRNA5) ??
- RS6495306 (CHRNA5) ??
- RS667282 (CHRNA5) ??
- RS680244 (CHRNA5) ??
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Top Gene-Substance Interactions
CHRNA5 Interacts with These Diseases
| Disease | Score |
Fixes
Do not start smoking or nicotine.
Substances That Increase CHRNA5
| Substances | Interaction | Organism | Category |
Substances That Decrease CHRNA5
| Substances | Interaction | Organism | Category |
Advanced Summary
The CHRNA5 gene produces a component of nicotinic receptors. Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of receptors that can mediate fast signal transmission at synapses (R), as well as increase the release of several neurotransmitters (R).
Nicotine activates these receptors. The most abundant receptor variation in the brain is the 4²2 subtype. Some 4²2 receptors also contain an 5 subunit (R). I
nclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization and calcium permeability (R). Higher CHRNA5 gene production results in more 5 subunit production and therefore more nictoine dependence risk (R).
Lower CHRNA5 gene production results in lower 5 subunit production. Inclusion of an 5 subunit in the nicotinic receptor significantly increases the rate of receptor desensitization (R), which increases nicotine dependence risk.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Acetylcholine-Activated Cation-Selective Channel Activity
- Acetylcholine Receptor Activity
- Ligand-Gated Ion Channel Activity
- Acetylcholine Binding
Biological Processes:
- Behavioral Response To Nicotine
- Chemical Synaptic Transmission
- Neuromuscular Synaptic Transmission
- Signal Transduction
- Synaptic Transmission, Cholinergic
- Transport