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  3. CDKN1A

CDKN1A (Cyclin dependent kinase inhibitor 1A)

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The Function of CDKN1A

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

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Protein names

Recommended name:

Cyclin-dependent kinase inhibitor 1

Alternative name(s):

CDK-interacting protein 1
Melanoma differentiation-associated protein 6
MDA-6
p21

CDKN1A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1059234 (CDKN1A) ??
  2. RS1801270 (CDKN1A) ??
  3. RS2395655 (CDKN1A) ??
  4. RS3829963 (CDKN1A) ??
  5. RS762624 (CDKN1A) ??

Top Gene-Substance Interactions

CDKN1A Interacts with These Diseases

Disease Score

Substances That Increase CDKN1A

Substances Interaction Organism Category

Substances That Decrease CDKN1A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • NF-kappaB1
  • C/EBPalpha
  • c-Myc
  • Sp1
  • IRF-1
  • E2F-1

Tissue specificity:

Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

Gene Pathways:

  • Immune System
  • Melanoma
  • Cellular responses to stress
  • Prostate cancer
  • p53 signaling pathway
  • Pathways in cancer
  • DNA Replication
  • Glioma
  • Signal Transduction
  • Disease
  • Chronic myeloid leukemia
  • Hepatitis C
  • Bladder cancer

Induction:

Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1.

Molecular Function:

  • Cyclin-Dependent Protein Kinase Activating Kinase Activity
  • Cyclin-Dependent Protein Serine/Threonine Kinase Inhibitor Activity
  • Metal Ion Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Animal Organ Regeneration
  • Cell Cycle Arrest
  • Cellular Response To Amino Acid Starvation
  • Cellular Response To Dna Damage Stimulus
  • Cellular Response To Extracellular Stimulus
  • Cellular Response To Gamma Radiation
  • Cellular Response To Heat
  • Cellular Response To Ionizing Radiation
  • Cellular Response To Uv-B
  • Cellular Senescence
  • Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
  • Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
  • G1/S Transition Of Mitotic Cell Cycle
  • G2/M Transition Of Mitotic Cell Cycle
  • Intestinal Epithelial Cell Maturation
  • Intrinsic Apoptotic Signaling Pathway
  • Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage By P53 Class Mediator
  • Mitotic Cell Cycle Arrest
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Phosphorylation
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Fibroblast Proliferation
  • Positive Regulation Of Programmed Cell Death
  • Positive Regulation Of Protein Kinase Activity
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Protein Stabilization
  • Ras Protein Signal Transduction
  • Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Regulation Of Dna Biosynthetic Process
  • Regulation Of Protein Import Into Nucleus, Translocation
  • Response To Arsenic-Containing Substance
  • Response To Corticosterone
  • Response To Hyperoxia
  • Response To Organonitrogen Compound
  • Response To Toxic Substance
  • Response To X-Ray
  • Stress-Induced Premature Senescence
  • Replicative Senescence
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| cyclin-dependent kinase inhibitor 1A (p21, Cip1)| A306_10163| AS27_08001| AS28_11395| cap20| CB1_069740010| Cdk1a| CDKI| cdk inhibitor CIP1 (p21)| CDK-interacting protein 1| CDK-interaction protein 1| cdkn1| cip1| Cyclin-dependent kinase inhibitor 1| cyclin-dependent kinase inhibitor 1A| cyclin-dependent kinase inhibitor 1A (P21)| DNA synthesis inhibitor| EGK_14841| GW7_15688| H920_11598| M91_20667| M959_11234| mda6| MDA-6| MDA_GLEAN10010707| melanoma differentiation-associated protein| melanoma differentiation associated protein 6| N300_03804| N301_15550| N302_13403| N303_12915| N305_03373| N306_14532| N307_09415| N308_15138| N309_02167| N310_00119| N321_10411| N330_06781| N331_06027| N332_12798| p16Xic2| P21| p21CIP1| p21WAF| p21/WAF1| PAL_GLEAN10007039| PANDA_002212| SDI1| TREES_T100014805| UV96| Waf1| wild-type p53-activated fragment 1| Y1Q_016509| Y956_09052| Z169_14358| cdkn1a

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