The Function of CDKN1A
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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Protein names
Recommended name:
Cyclin-dependent kinase inhibitor 1Alternative name(s):
CDK-interacting protein 1Melanoma differentiation-associated protein 6
MDA-6
p21
- RS1059234 (CDKN1A) ??
- RS1801270 (CDKN1A) ??
- RS2395655 (CDKN1A) ??
- RS3829963 (CDKN1A) ??
- RS762624 (CDKN1A) ??
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Top Gene-Substance Interactions
CDKN1A Interacts with These Diseases
| Disease | Score |
Substances That Increase CDKN1A
| Substances | Interaction | Organism | Category |
Substances That Decrease CDKN1A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
Gene Pathways:
Induction:
Activated by p53/TP53, mezerein (antileukemic compound) and IFNB1. Repressed by HDAC1.
Molecular Function:
- Cyclin-Dependent Protein Serine/Threonine Kinase Inhibitor Activity
- Cyclin-Dependent Protein Kinase Activating Kinase Activity
- Ubiquitin Protein Ligase Binding
- Metal Ion Binding
Biological Processes:
- Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- G1/S Transition Of Mitotic Cell Cycle
- G2/M Transition Of Mitotic Cell Cycle
- Cellular Response To Dna Damage Stimulus
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
- Cell Cycle Arrest
- Ras Protein Signal Transduction
- Negative Regulation Of Cell Proliferation
- Response To Toxic Substance
- Response To X-Ray
- Response To Organonitrogen Compound
- Negative Regulation Of Gene Expression
- Negative Regulation Of Cell Growth
- Positive Regulation Of B Cell Proliferation
- Animal Organ Regeneration
- Cellular Response To Extracellular Stimulus
- Regulation Of Protein Import Into Nucleus, Translocation
- Cellular Response To Amino Acid Starvation
- Cellular Response To Heat
- Negative Regulation Of Phosphorylation
- Intrinsic Apoptotic Signaling Pathway In Response To Dna Damage By P53 Class Mediator
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Programmed Cell Death
- Negative Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Positive Regulation Of Protein Kinase Activity
- Response To Arsenic-Containing Substance
- Positive Regulation Of Fibroblast Proliferation
- Protein Stabilization
- Response To Corticosterone
- Response To Hyperoxia
- Intestinal Epithelial Cell Maturation
- Cellular Response To Ionizing Radiation
- Cellular Response To Gamma Radiation
- Cellular Response To Uv-B
- Mitotic Cell Cycle Arrest
- Cellular Senescence
- Replicative Senescence
- Stress-Induced Premature Senescence
- Intrinsic Apoptotic Signaling Pathway
- Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Regulation Of Dna Biosynthetic Process
- Positive Regulation Of Reactive Oxygen Species Metabolic Process