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  3. ABCC1

ABCC1 (ATP binding cassette subfamily C member 1)

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Summary of ABCC1

ABCC1 is part of a group of genes that transports molecules across cellular membranes (within and through cells) [R1]. This gene is involved in multidrug resistance [R2] and metabolism [R3]. It is also responsible for the transport of antiviral drugs and is affiliated with resistance to anticancer drugs [R4].

Also known as multidrug resistance protein 1 (MRP1).

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The Function of ABCC1

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.

Protein names

Recommended name:

Multidrug resistance-associated protein 1

Alternative name(s):

ATP-binding cassette sub-family C member 1
Leukotriene C(4
LTC4 transporter

ABCC1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS119774 (ABCC1) ??
  2. RS2062541 (ABCC1) ??
  3. RS212093 (ABCC1) ??
  4. RS2238476 (ABCC1) ??
  5. RS246221 (ABCC1) ??
  6. RS246234 (ABCC1) ??
  7. RS246240 (ABCC1) ??
  8. RS35592 (ABCC1) ??
  9. RS35605 (ABCC1) ??
  10. RS35621 (ABCC1) ??
  11. RS3743527 (ABCC1) ??
  12. RS3765129 (ABCC1) ??
  13. RS3784862 (ABCC1) ??
  14. RS4148356 (ABCC1) ??
  15. RS4148382 (ABCC1) ??
  16. RS45511401 (ABCC1) ??
  17. RS4781699 (ABCC1) ??
  18. RS924135 (ABCC1) ??

Top Gene-Substance Interactions

ABCC1 Interacts with These Diseases

Disease Score

Fixes

Inhibitors of ABCC1:

  • Guggulsterone [R]

Substances That Increase ABCC1

Substances Interaction Organism Category

Substances That Decrease ABCC1

Substances Interaction Organism Category

Advanced Summary

ABCC1 is part of a group of genes that transports molecules across cellular membranes (within and through cells) [R1].

This gene is involved in multidrug resistance [R2] and metabolism [R3]. It is also responsible for the transport of antiviral drugs and is affiliated with resistance to anticancer drugs [R4].

A problematic ABCC1 gene is associated with Dublin-johnson syndrome and microsporidiosis [R3]. Dubin-johnson syndrome is a rare, inherited condition that is associated with metabolic issues and causes a black liver [R5]. However, microsporidiosis is a NON-hereditary (not genetic), infectious disease [R6].

A major attribute of ABCC1 is the transport of a multidrug resistant protein that gives cancer cells resistance to drugs. The major function of ABCC1, however, is to transport leukotriene C4 [R7].

An imbalance, specifically a surplus, of leukotriene C4 can constrict airways and create symptoms of asthma [R8]. However, there doesn’t appear to be a causal link between asthma and the gene ABCC1. There is, however, a clear link between ABCC1 (and ABCC2 [R5]) and Dublin-johnson syndrome [R3].

The only symptoms of Dublin johnson syndrome is a pigmentation around the liver (this is also the cause) and a slight abdominal pain [R9]. Treatment is unnecessary, as most patients live normal life spans without the syndrome’s symptoms having any major effects [R10].

However, it is probably not a good idea to put any further stresses on the liver. As for this gene’s drug-resisting abilities [R3], research is being done to combat drug-resistance through the use of nanomedicine [R11].

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • Egr-1
  • AP-1
  • Max
  • c-Jun

Tissue specificity:

Lung, testis and peripheral blood mononuclear cells.

Gene Pathways:

  • Metabolism
  • Disease
  • Transmembrane transport of small molecules
  • Vitamin digestion and absorption
  • ABC transporters

Molecular Function:

  • Atpase Activity
  • Atpase Activity, Coupled To Transmembrane Movement Of Substances
  • Atpase-Coupled Anion Transmembrane Transporter Activity
  • Atp Binding
  • Cobalamin-Transporting Atpase Activity
  • Transporter Activity

Biological Processes:

  • Cobalamin Metabolic Process
  • Leukotriene Metabolic Process
  • Transmembrane Transport
  • Transport

Drug Bank:

  • Aminohippurate
  • Atazanavir
  • Conjugated Estrogens
  • Amprenavir
  • Atorvastatin
  • Colchicine
  • Cyclosporine
  • Dactinomycin
  • Daunorubicin
  • Diclofenac
  • Docetaxel
  • Epirubicin
  • Erythromycin
  • Etoposide
  • Fluorescein
  • Glutathione
  • Ibuprofen
  • Idarubicin
  • Indinavir
  • Rifampicin
  • Rosuvastatin
  • Vandetanib
  • Vemurafenib
  • Zoledronate
  • Irinotecan
  • Lamivudine
  • Methotrexate
  • Mifepristone
  • Mitoxantrone
  • Ofloxacin
  • Paclitaxel
  • Probenecid
  • Progesterone
  • Ritonavir
  • Saquinavir
  • Saxagliptin
  • Verapamil
  • Vinblastine
  • Vincristine
  • Abiraterone
  • Cholic Acid
  • Doxorubicin
  • Glyburide
  • Indomethacin
  • Ivermectin
  • Phenobarbital
  • Sulfinpyrazone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| multidrug resistance protein 1| A306_07007| abc29| ABCC| Abcc1a| Abcc1b| AS27_15071| AS28_14510| ATP-binding cassette, sub-family C (CFTR/MRP), member 1| ATP-binding cassette, subfamily C (CFTR/MRP), member 1| ATP-binding cassette sub-family C ( CFTR/MRP) member 1a| ATP-binding cassette, sub-family C (CFTR/MRP), member 1a| ATP-binding cassette, sub-family C (CFTR/MRP), member 1b| ATP-binding cassette sub-family C member 1| ATP-binding cassette, sub-family C, member 1| ATP-binding cassette superfamily member C1| ATP-binding cassette transporter sub-family C member 1| ATP-binding cassette transporter variant ABCC1delta-ex13| ATP-binding cassette transporter variant ABCC1delta-ex13&14| ATP-binding cassette transporter variant ABCC1delta-ex25| ATP-binding cassette transporter variant ABCC1delta-ex25&26| Avcc1a| CB1_000394020| D623_10032211| GS-X| H920_17937| I79_009387| Leukotriene C(4) transporter| LTC4 transporter| M91_01934| M959_02470| MDA_GLEAN10012917| Mdrap| MRP| mrp1| Multidrug resistance-associated protein 1| multidrug resistance protein 1A| multidrug resistance protein 1B| multiple drug resistance-associated protein| multiple drug resistance protein 1| N300_08935| N303_11864| N306_05549| N307_05916| N309_05724| N310_06379| N311_06946| N312_01578| N320_02877| N324_07792| N325_06191| N326_12093| N327_09956| N329_09171| N330_00597| N333_07742| N335_13283| N336_02811| N339_06004| N341_11337| PAL_GLEAN10009743| PANDA_016754| TREES_T100018490| UY3_05487| Y956_00473| abcc1

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