ABCC1 is part of a group of genes that transports molecules across cellular membranes (within and through cells) [R1].

This gene is involved in multidrug resistance [R2] and metabolism [R3]. It is also responsible for the transport of antiviral drugs and is affiliated with resistance to anticancer drugs [R4].

A problematic ABCC1 gene is associated with Dublin-johnson syndrome and microsporidiosis [R3]. Dubin-johnson syndrome is a rare, inherited condition that is associated with metabolic issues and causes a black liver [R5]. However, microsporidiosis is a NON-hereditary (not genetic), infectious disease [R6].

A major attribute of ABCC1 is the transport of a multidrug resistant protein that gives cancer cells resistance to drugs. The major function of ABCC1, however, is to transport leukotriene C4 [R7].

An imbalance, specifically a surplus, of leukotriene C4 can constrict airways and create symptoms of asthma [R8]. However, there doesn’t appear to be a causal link between asthma and the gene ABCC1. There is, however, a clear link between ABCC1 (and ABCC2 [R5]) and Dublin-johnson syndrome [R3].

The only symptoms of Dublin johnson syndrome is a pigmentation around the liver (this is also the cause) and a slight abdominal pain [R9]. Treatment is unnecessary, as most patients live normal life spans without the syndrome’s symptoms having any major effects [R10].

However, it is probably not a good idea to put any further stresses on the liver. As for this gene’s drug-resisting abilities [R3], research is being done to combat drug-resistance through the use of nanomedicine [R11].

The following transcription factors affect gene expression:

• PPAR-gamma1
• PPAR-gamma2
• Egr-1
• AP-1
• Max
• c-Jun

Tissue specificity:

Lung, testis and peripheral blood mononuclear cells.

Molecular Function:

• Transporter Activity
• Atp Binding
• Cobalamin-Transporting Atpase Activity
• Atpase Activity
• Atpase Activity, Coupled To Transmembrane Movement Of Substances
• Atpase-Coupled Anion Transmembrane Transporter Activity

Biological Processes:

• Leukotriene Metabolic Process
• Transport
• Cobalamin Metabolic Process
• Transmembrane Transport

Drug Bank:

• Aminohippurate
• Atazanavir
• Conjugated Estrogens
• Amprenavir
• Atorvastatin
• Colchicine
• Cyclosporine
• Dactinomycin
• Daunorubicin
• Diclofenac
• Docetaxel
• Epirubicin
• Erythromycin
• Etoposide
• Fluorescein
• Glutathione
• Ibuprofen
• Idarubicin
• Indinavir
• Rifampicin
• Rosuvastatin
• Vandetanib
• Vemurafenib
• Zoledronate
• Irinotecan
• Lamivudine
• Methotrexate
• Mifepristone
• Mitoxantrone
• Ofloxacin
• Paclitaxel
• Probenecid
• Progesterone
• Ritonavir
• Saquinavir
• Saxagliptin
• Verapamil
• Vinblastine
• Vincristine
• Abiraterone
• Cholic Acid
• Doxorubicin
• Glyburide
• Indomethacin
• Ivermectin
• Phenobarbital
• Sulfinpyrazone