Summary of ABCC1
ABCC1 is part of a group of genes that transports molecules across cellular membranes (within and through cells) [R1]. This gene is involved in multidrug resistance [R2] and metabolism [R3]. It is also responsible for the transport of antiviral drugs and is affiliated with resistance to anticancer drugs [R4].
Also known as multidrug resistance protein 1 (MRP1).
The Function of ABCC1
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Protein names
Recommended name:
Multidrug resistance-associated protein 1Alternative name(s):
ATP-binding cassette sub-family C member 1Leukotriene C(4
LTC4 transporter
- RS119774 (ABCC1) ??
- RS2062541 (ABCC1) ??
- RS212093 (ABCC1) ??
- RS2238476 (ABCC1) ??
- RS246221 (ABCC1) ??
- RS246234 (ABCC1) ??
- RS246240 (ABCC1) ??
- RS35592 (ABCC1) ??
- RS35605 (ABCC1) ??
- RS35621 (ABCC1) ??
- RS3743527 (ABCC1) ??
- RS3765129 (ABCC1) ??
- RS3784862 (ABCC1) ??
- RS4148356 (ABCC1) ??
- RS4148382 (ABCC1) ??
- RS45511401 (ABCC1) ??
- RS4781699 (ABCC1) ??
- RS924135 (ABCC1) ??
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Top Gene-Substance Interactions
ABCC1 Interacts with These Diseases
Disease | Score |
Fixes
Inhibitors of ABCC1:
- Guggulsterone [R]
Substances That Increase ABCC1
Substances | Interaction | Organism | Category |
Substances That Decrease ABCC1
Substances | Interaction | Organism | Category |
Advanced Summary
ABCC1 is part of a group of genes that transports molecules across cellular membranes (within and through cells) [R1].
This gene is involved in multidrug resistance [R2] and metabolism [R3]. It is also responsible for the transport of antiviral drugs and is affiliated with resistance to anticancer drugs [R4].
A problematic ABCC1 gene is associated with Dublin-johnson syndrome and microsporidiosis [R3]. Dubin-johnson syndrome is a rare, inherited condition that is associated with metabolic issues and causes a black liver [R5]. However, microsporidiosis is a NON-hereditary (not genetic), infectious disease [R6].
A major attribute of ABCC1 is the transport of a multidrug resistant protein that gives cancer cells resistance to drugs. The major function of ABCC1, however, is to transport leukotriene C4 [R7].
An imbalance, specifically a surplus, of leukotriene C4 can constrict airways and create symptoms of asthma [R8]. However, there doesn’t appear to be a causal link between asthma and the gene ABCC1. There is, however, a clear link between ABCC1 (and ABCC2 [R5]) and Dublin-johnson syndrome [R3].
The only symptoms of Dublin johnson syndrome is a pigmentation around the liver (this is also the cause) and a slight abdominal pain [R9]. Treatment is unnecessary, as most patients live normal life spans without the syndrome’s symptoms having any major effects [R10].
However, it is probably not a good idea to put any further stresses on the liver. As for this gene’s drug-resisting abilities [R3], research is being done to combat drug-resistance through the use of nanomedicine [R11].
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Lung, testis and peripheral blood mononuclear cells.
Gene Pathways:
Molecular Function:
- Atpase Activity
- Atpase Activity, Coupled To Transmembrane Movement Of Substances
- Atpase-Coupled Anion Transmembrane Transporter Activity
- Atp Binding
- Cobalamin-Transporting Atpase Activity
- Transporter Activity
Biological Processes:
Drug Bank:
- Aminohippurate
- Atazanavir
- Conjugated Estrogens
- Amprenavir
- Atorvastatin
- Colchicine
- Cyclosporine
- Dactinomycin
- Daunorubicin
- Diclofenac
- Docetaxel
- Epirubicin
- Erythromycin
- Etoposide
- Fluorescein
- Glutathione
- Ibuprofen
- Idarubicin
- Indinavir
- Rifampicin
- Rosuvastatin
- Vandetanib
- Vemurafenib
- Zoledronate
- Irinotecan
- Lamivudine
- Methotrexate
- Mifepristone
- Mitoxantrone
- Ofloxacin
- Paclitaxel
- Probenecid
- Progesterone
- Ritonavir
- Saquinavir
- Saxagliptin
- Verapamil
- Vinblastine
- Vincristine
- Abiraterone
- Cholic Acid
- Doxorubicin
- Glyburide
- Indomethacin
- Ivermectin
- Phenobarbital
- Sulfinpyrazone