Summary of IFNG
This gene encodes a protein that helps trigger a response to infections. Interferon-gamma is a Th1 driven inflammatory cytokine.
Mutations in this gene are associated with an increased susceptibility to infections and autoimmune diseases (R).
The Function of IFNG
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Protein names
Recommended name:
Interferon gammaAlternative name(s):
IFN-gammaImmune interferon
- RS1861493 (IFNG) ??
- RS1861494 (IFNG) ??
- RS2069705 (IFNG) ??
- RS2069707 (IFNG) ??
- RS2069718 (IFNG) ??
- RS2069727 (IFNG) ??
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Top Gene-Substance Interactions
IFNG Interacts with These Diseases
| Disease | Score |
Substances That Increase IFNG
| Substances | Interaction | Organism | Category |
Substances That Decrease IFNG
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Aplastic anemiaHuman immunodeficiency virus type 1, susceptibility toHepatitis c virus, susceptibility toTuberous sclerosis 2Mycobacterium tuberculosis, susceptibility toFrom UniProt: Aplastic anemia (AA): A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. [MIM:609135]
From NCBI Gene: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015] From UniProt: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Released primarily from activated T lymphocytes.
Gene Pathways:
- Systemic lupus erythematosus
- Antigen processing and presentation
- Natural killer cell mediated cytotoxicity
- Regulation of autophagy
- T cell receptor signaling pathway
- Rheumatoid arthritis
- Tuberculosis
- TGF-beta signaling pathway
- Leishmaniasis
- Toxoplasmosis
- Allograft rejection
- Measles
- Immune System
- Type I diabetes mellitus
- Proteasome
- African trypanosomiasis
- Graft-versus-host disease
- Osteoclast differentiation
- Jak-STAT signaling pathway
- Chagas disease (American trypanosomiasis)
- Cytokine-cytokine receptor interaction
- Amoebiasis
- Malaria
Molecular Function:
Biological Processes:
- Protein Import Into Nucleus, Translocation
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Neutrophil Apoptotic Process
- Regulation Of The Force Of Heart Contraction
- Adaptive Immune Response
- Cd8-Positive, Alpha-Beta T Cell Differentiation Involved In Immune Response
- Apoptotic Process
- Movement Of Cell Or Subcellular Component
- Humoral Immune Response
- Cell Cycle Arrest
- Cell Surface Receptor Signaling Pathway
- Positive Regulation Of Cell Proliferation
- Response To Virus
- Positive Regulation Of Autophagy
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Positive Regulation Of Epithelial Cell Migration
- Antigen Processing And Presentation
- Neutrophil Chemotaxis
- Negative Regulation Of Epithelial Cell Differentiation
- Endoplasmic Reticulum Unfolded Protein Response
- Negative Regulation Of Myelination
- Positive Regulation Of Synaptic Transmission, Cholinergic
- Negative Regulation Of Interleukin-17 Production
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Interleukin-23 Production
- Positive Regulation Of Tumor Necrosis Factor Production
- Positive Regulation Of Cd4-Positive, Cd25-Positive, Alpha-Beta Regulatory T Cell Differentiation Involved In Immune Response
- Positive Regulation Of Peptidyl-Serine Phosphorylation Of Stat Protein
- Positive Regulation Of Smooth Muscle Cell Apoptotic Process
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- Defense Response To Bacterium
- Defense Response To Protozoan
- Negative Regulation Of Growth Of Symbiont In Host
- Positive Regulation Of Chemokine Biosynthetic Process
- Positive Regulation Of Interleukin-12 Biosynthetic Process
- Positive Regulation Of Mhc Class Ii Biosynthetic Process
- Positive Regulation Of Interleukin-6 Biosynthetic Process
- Positive Regulation Of Nitric Oxide Biosynthetic Process
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Osteoclast Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Fibroblast Proliferation
- Positive Regulation Of Isotype Switching To Igg Isotypes
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Interleukin-1 Beta Secretion
- Regulation Of Insulin Secretion
- T Cell Receptor Signaling Pathway
- Sensory Perception Of Mechanical Stimulus
- Positive Regulation Of Membrane Protein Ectodomain Proteolysis
- Defense Response To Virus
- Positive Regulation Of Killing Of Cells Of Other Organism
- Regulation Of Glial Cell Proliferation
- Interferon-Gamma-Mediated Signaling Pathway
- Regulation Of Interferon-Gamma-Mediated Signaling Pathway
- Positive Regulation Of Fructose 1,6-Bisphosphate 1-Phosphatase Activity
- Positive Regulation Of Fructose 1,6-Bisphosphate Metabolic Process
- Positive Regulation Of Vitamin D Biosynthetic Process
- Positive Regulation Of Calcidiol 1-Monooxygenase Activity
- Cellular Response To Lipopolysaccharide
- Cellular Response To Interleukin-18
- Negative Regulation Of Glomerular Mesangial Cell Proliferation
- Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
- Extrinsic Apoptotic Signaling Pathway
- Regulation Of Neuronal Action Potential
- Positive Regulation Of Exosomal Secretion
- Positive Regulation Of Tumor Necrosis Factor (Ligand) Superfamily Member 11 Production
- Regulation Of Hepatocyte Proliferation