Summary of IFNG
This gene encodes a protein that helps trigger a response to infections. Interferon-gamma is a Th1 driven inflammatory cytokine.
Mutations in this gene are associated with an increased susceptibility to infections and autoimmune diseases (R).
The Function of IFNG
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Protein names
Recommended name:
Interferon gammaAlternative name(s):
IFN-gammaImmune interferon
- RS1861493 (IFNG) ??
- RS1861494 (IFNG) ??
- RS2069705 (IFNG) ??
- RS2069707 (IFNG) ??
- RS2069718 (IFNG) ??
- RS2069727 (IFNG) ??
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Top Gene-Substance Interactions
IFNG Interacts with These Diseases
| Disease | Score |
Substances That Increase IFNG
| Substances | Interaction | Organism | Category |
Substances That Decrease IFNG
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Aplastic anemiaHuman immunodeficiency virus type 1, susceptibility toHepatitis c virus, susceptibility toTuberous sclerosis 2Mycobacterium tuberculosis, susceptibility toFrom UniProt: Aplastic anemia (AA): A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. [MIM:609135]
From NCBI Gene: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015] From UniProt: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Released primarily from activated T lymphocytes.
Gene Pathways:
- Rheumatoid arthritis
- Immune System
- Cytokine-cytokine receptor interaction
- Chagas disease (American trypanosomiasis)
- Tuberculosis
- Toxoplasmosis
- Systemic lupus erythematosus
- Leishmaniasis
- Allograft rejection
- T cell receptor signaling pathway
- Regulation of autophagy
- Type I diabetes mellitus
- Graft-versus-host disease
- Osteoclast differentiation
- Antigen processing and presentation
- Measles
- Proteasome
- Malaria
- Amoebiasis
- Jak-STAT signaling pathway
- TGF-beta signaling pathway
- Natural killer cell mediated cytotoxicity
- African trypanosomiasis
Molecular Function:
Biological Processes:
- Adaptive Immune Response
- Antigen Processing And Presentation
- Apoptotic Process
- Cd8-Positive, Alpha-Beta T Cell Differentiation Involved In Immune Response
- Cell Cycle Arrest
- Cell Surface Receptor Signaling Pathway
- Cellular Response To Interleukin-18
- Cellular Response To Lipopolysaccharide
- Defense Response To Bacterium
- Defense Response To Protozoan
- Defense Response To Virus
- Endoplasmic Reticulum Unfolded Protein Response
- Extrinsic Apoptotic Signaling Pathway
- Humoral Immune Response
- Interferon-Gamma-Mediated Signaling Pathway
- Movement Of Cell Or Subcellular Component
- Negative Regulation Of Epithelial Cell Differentiation
- Negative Regulation Of Fibroblast Proliferation
- Negative Regulation Of Gene Expression
- Negative Regulation Of Glomerular Mesangial Cell Proliferation
- Negative Regulation Of Growth Of Symbiont In Host
- Negative Regulation Of Interleukin-17 Production
- Negative Regulation Of Myelination
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Neutrophil Apoptotic Process
- Neutrophil Chemotaxis
- Positive Regulation Of Autophagy
- Positive Regulation Of Calcidiol 1-Monooxygenase Activity
- Positive Regulation Of Cd4-Positive, Cd25-Positive, Alpha-Beta Regulatory T Cell Differentiation Involved In Immune Response
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Chemokine Biosynthetic Process
- Positive Regulation Of Epithelial Cell Migration
- Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
- Positive Regulation Of Exosomal Secretion
- Positive Regulation Of Fructose 1,6-Bisphosphate 1-Phosphatase Activity
- Positive Regulation Of Fructose 1,6-Bisphosphate Metabolic Process
- Positive Regulation Of Gene Expression
- Positive Regulation Of Interleukin-12 Biosynthetic Process
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Interleukin-1 Beta Secretion
- Positive Regulation Of Interleukin-23 Production
- Positive Regulation Of Interleukin-6 Biosynthetic Process
- Positive Regulation Of Isotype Switching To Igg Isotypes
- Positive Regulation Of Killing Of Cells Of Other Organism
- Positive Regulation Of Membrane Protein Ectodomain Proteolysis
- Positive Regulation Of Mhc Class Ii Biosynthetic Process
- Positive Regulation Of Neuron Differentiation
- Positive Regulation Of Nitric Oxide Biosynthetic Process
- Positive Regulation Of Osteoclast Differentiation
- Positive Regulation Of Peptidyl-Serine Phosphorylation Of Stat Protein
- Positive Regulation Of Smooth Muscle Cell Apoptotic Process
- Positive Regulation Of Synaptic Transmission, Cholinergic
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Tumor Necrosis Factor (Ligand) Superfamily Member 11 Production
- Positive Regulation Of Tumor Necrosis Factor Production
- Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- Positive Regulation Of Vitamin D Biosynthetic Process
- Protein Import Into Nucleus, Translocation
- Regulation Of Glial Cell Proliferation
- Regulation Of Hepatocyte Proliferation
- Regulation Of Insulin Secretion
- Regulation Of Interferon-Gamma-Mediated Signaling Pathway
- Regulation Of Neuronal Action Potential
- Regulation Of The Force Of Heart Contraction
- Response To Virus
- Sensory Perception Of Mechanical Stimulus
- T Cell Receptor Signaling Pathway