rs964184

Chromosome : 11 , Position: 116778201

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: C

Associated Genes

SIDT2

PCSK7

ZPR1

SIK3

APOA5

TAGLN

PAFAH1B2

BUD13

RNF214

APOA1

APOA4

APOC3

DPAGT1

H2AX

CEP164

Traits

Trait	Variant	PMID	Author (year)
Mean sphered cell volume	C	Unknown journal	UKB Neale v2 (2018)
Mean corpuscular volume	C	Unknown journal	UKB Neale v2 (2018)
Stem cell factor levels	C	Nat Metab	Folkersen L (2020)
Mean spheric corpuscular volume	C	Cell	Vuckovic D (2020)
Mean reticulocyte volume	C	Cell	Vuckovic D (2020)
Mean corpuscular hemoglobin concentration	C	Cell	Vuckovic D (2020)
Reticulocyte fraction of red cells	C	Cell	Vuckovic D (2020)
Serum 25-Hydroxyvitamin D levels	C	Nat Commun	Revez JA (2020)
Platelet distribution width	C	Unknown journal	UKB Neale v2 (2018)
Reticulocyte count	C	Cell	Astle WJ (2016)
High light scatter reticulocyte count	C	Cell	Astle WJ (2016)
Mean platelet volume	C	Cell	Astle WJ (2016)
High light scatter reticulocyte percentage of red cells	C	Cell	Astle WJ (2016)
Mean corpuscular haemoglobin concentration	C	Unknown journal	UKB Neale v2 (2018)
Red blood cell (erythrocyte) distribution width	C	Unknown journal	UKB Neale v2 (2018)
Eosinophil counts	C	Cell	Vuckovic D (2020)
Eosinophil percentage of white cells	C	Cell	Vuckovic D (2020)
Monocyte count	C	Cell	Chen MH (2020)
"Hyperlipidaemia, other/unspecified"	C	Unknown journal	FINNGEN_R5 (2021)
Abdominal aortic aneurysm	C	Circulation	Klarin D (2020)
Age-related disease endophenotypes	C	Front Genet	He L (2016)
Age-related diseases, mortality and associated endophenotypes	C	Front Genet	He L (2016)
Apolipoprotein B levels	C	PLoS Med	Richardson TG (2020)
Aspartate aminotransferase levels	C	Nat Commun	Chen VL (2021)
Bezafibrate \| treatment/medication code	C	Unknown journal	UKB Neale v2 (2018)
Blood metabolite levels [X-03094]	C	Nat Genet	Shin SY (2014)
Blood protein levels [ANGPTL3, 10391_1_3]	C	Science	Emilsson V (2018)
Blood protein levels [APOA5, 11318_20_3]	C	Science	Emilsson V (2018)
Blood protein levels [NXPH2, 9511_61_3]	C	Science	Emilsson V (2018)
Blood protein levels [PCSK7, 4459_68_2]	C	Science	Emilsson V (2018)
Cardiovascular disease	C	Am J Hum Genet	Kichaev G (2018)
Cholesterol efflux capacity (ABCA-1 dependent assay)	C	J Am Heart Assoc	Low-Kam C (2018)
Cholesterol lowering medication \| medication for cholesterol, blood pressure or diabetes	C	Unknown journal	UKB Neale v2 (2018)
Cholesterol lowering medication \| medication for cholesterol, blood pressure, diabetes, or take exogenous hormones	C	Unknown journal	UKB Neale v2 (2018)
Cholesterol, total	C	Nat Genet	Surakka I (2015)
Cholesterol, total [Hispanic]	C	Sci Rep	Below JE (2016)
Coronary artery disease	C	Circ Res	van der Harst P (2017)
Coronary artery disease or large artery stroke	C	Stroke	Dichgans M (2013)
Coronary heart disease	C	Nat Genet	Schunkert H (2011)
Disorders of lipoid metabolism	C	Unknown journal	UKB SAIGE (2018)
Ezetimibe \| treatment/medication code	C	Unknown journal	UKB Neale v2 (2018)
Fasting triglyceride levels	C	Circ Genom Precis Med	Ibi D (2020)
Fenofibrate \| treatment/medication code	C	Unknown journal	UKB Neale v2 (2018)
HDL cholesterol	C	Nat Genet	Surakka I (2015)
HDL cholesterol [Hispanic]	C	Am J Hum Genet	Coram MA (2013)
HDL cholesterol levels	C	Nat Genet	Bentley AR (2019)
HDL cholesterol levels x long total sleep time interaction (2df test)	C	Nat Commun	Noordam R (2019)
HDL cholesterol levels x short total sleep time interaction (2df test)	C	Nat Commun	Noordam R (2019)
High density lipoprotein cholesterol levels	C	Nat Genet	Hoffmann TJ (2018)
High density lipoprotein cholesterol levels [EA]	C	Nat Genet	Hoffmann TJ (2018)
Hypercholesterolemia	C	Unknown journal	UKB SAIGE (2018)
Hyperlipidemia	C	Unknown journal	UKB SAIGE (2018)
Hypertriglyceridemia	C	Nat Genet	Johansen CT (2010)
LDL cholesterol	C	Nat Genet	Surakka I (2015)
LDL cholesterol levels	C	PLoS Med	Richardson TG (2020)
LDL cholesterol levels [EA]	C	Nat Genet	Bentley AR (2019)
LDL cholesterol levels [Trans-ethnic initial]	C	Hum Mol Genet	Spracklen CN (2017)
Lipid or lipoprotein levels [Triglycerides]	C	PLoS One	Wood AR (2013)
Lipitor 10mg tablet \| treatment/medication code	C	Unknown journal	UKB Neale v2 (2018)
Lipoprotein-associated phospholipase A2 activity and mass [Activity concentrations]	C	Eur Heart J	Grallert H (2011)
Low density lipoprotein cholesterol levels	C	Nat Genet	Hoffmann TJ (2018)
Low density lipoprotein cholesterol levels [EA]	C	Nat Genet	Hoffmann TJ (2018)
Medication use (HMG CoA reductase inhibitors)	C	Nat Commun	Wu Y (2019)
Medication use (agents acting on the renin-angiotensin system)	C	Nat Commun	Wu Y (2019)
Medication use (antithrombotic agents)	C	Nat Commun	Wu Y (2019)
Medication use (salicylic acid and derivatives)	C	Nat Commun	Wu Y (2019)
Metabolic syndrome	C	Metab Syndr Relat Disord	Lind L (2019)
Metabolic syndrome [TG]	C	Circ Cardiovasc Genet	Kristiansson K (2012)
Metabolite levels	C	PLoS Genet	Inouye M (2012)
Metabolite levels (lipoprotein measures) [Triglycerides in small VLDL]	C	Nat Commun	Kettunen J (2016)
Metabolite levels [DAG 34:2]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [DAG 36:1]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [DAG 36:2]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [TAG 52:4]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [TAG 52:5]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [TAG 54:2]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [TAG 54:3]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [TAG 54:5]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [TAG 56:10]	C	Cell Metab	Rhee EP (2013)
Metabolite levels [TAG 56:3]	C	Cell Metab	Rhee EP (2013)
None of the above \| medication for cholesterol, blood pressure or diabetes	C	Unknown journal	UKB Neale v2 (2018)
Phospholipid levels (plasma) [proportions]	C	PLoS Genet	Demirkan A (2012)
Platelet count	C	Cell	Chen MH (2020)
Postprandial triglyceride levels	C	Circ Genom Precis Med	Ibi D (2020)
Postprandial triglyceride response to high fat diet meal [AUC]	C	Metabolism	Wojczynski MK (2015)
Red cell distribution width	C	Cell	Chen MH (2020)
Response to Vitamin E supplementation [alpha-TOH]	C	J Nutr	Major JM (2012)
Serum metabolite levels [1-stearoyl-2-arachidonoyl-GPI (18:0/20:4]	C	Am J Hum Genet	Feofanova EV (2020)
Serum metabolite levels [1-stearoyl-2-linoleoyl-GPI (18:0/18:2]	C	Am J Hum Genet	Feofanova EV (2020)
Serum metabolite levels [linoleoyl-linoleoyl-glycerol (18:2/18:2) [1]*]	C	Am J Hum Genet	Feofanova EV (2020)
Serum metabolite levels [oleoyl-linoleoyl-glycerol (18:1/18:2) [1]]	C	Am J Hum Genet	Feofanova EV (2020)
Serum metabolite levels [oleoyl-linoleoyl-glycerol (18:1/18:2) [2]]	C	Am J Hum Genet	Feofanova EV (2020)
Serum metabolite levels [palmitoleoyl-linoleoyl-glycerol (16:1/18:2) [1]*]	C	Am J Hum Genet	Feofanova EV (2020)
Serum metabolite levels [palmitoyl-linoleoyl-glycerol (16:0/18:2) [1]*]	C	Am J Hum Genet	Feofanova EV (2020)
Serum metabolite levels [palmitoyl-linoleoyl-glycerol (16:0/18:2) [2]*]	C	Am J Hum Genet	Feofanova EV (2020)
Statin medication	C	Unknown journal	FINNGEN_R5 (2021)
Total cholesterol levels	C	Nature	Wojcik GL (2019)
Total cholesterol levels [EA]	C	Nat Genet	Hoffmann TJ (2018)
Total cholesterol levels [Hispanic]	C	Nat Genet	Hoffmann TJ (2018)
Total cholesterol levels [Trans-ethnic initial]	C	Hum Mol Genet	Spracklen CN (2017)
Total triglycerides levels	C	Nat Commun	Tang CS (2015)
Triacylglyceride levels [TAG(50:3;0]	C	Nat Commun	Tabassum R (2019)
Triacylglyceride levels [TAG(51:3;0]	C	Nat Commun	Tabassum R (2019)
Triacylglyceride levels [TAG(52:3;0]	C	Nat Commun	Tabassum R (2019)
Triacylglyceride levels [TAG(52:4;0]	C	Nat Commun	Tabassum R (2019)
Triacylglyceride levels [TAG(54:3;0]	C	Nat Commun	Tabassum R (2019)
Triacylglyceride levels [TAG(56:4;0]	C	Nat Commun	Tabassum R (2019)
Triacylglyceride levels [Total_TAG]	C	Nat Commun	Tabassum R (2019)
Triacylglycerol 56:2 levels	C	PLoS One	Geidenstam N (2019)
Triglyceride levels	C	Nature	Wojcik GL (2019)
Triglyceride levels [Filipino]	C	PeerJ	Andaleon A (2018)
Triglyceride levels [Indian]	C	J Hum Genet	Bandesh K (2019)
Triglyceride levels in HIV infection [EA]	C	BMC Med	Chang H (2020)
Triglyceride levels x long total sleep time interaction (2df test)	C	Nat Commun	Noordam R (2019)
Triglyceride levels x short total sleep time interaction (2df test)	C	Nat Commun	Noordam R (2019)
Triglycerides	C	Nat Genet	Surakka I (2015)
Triglycerides [EA]	C	Nat Genet	Hoffmann TJ (2018)
Triglycerides [Hispanic]	C	Am J Hum Genet	Coram MA (2013)
Triglycerides x physical activity interaction (2df test)	C	Nat Commun	Kilpelainen TO (2019)
Very low density lipoprotein cholesterol levels	C	Nat Commun	Southam L (2017)
Vitamin D insufficiency	C	BMJ Nutr Prev Health	Amin HA (2021)
Vitamin E levels	C	Hum Mol Genet	Major JM (2011)
Vitamin levels [Vitamin E alpha tocopherol]	C	PLoS One	Wood AR (2013)

Summary

The rs964184(G;G) genotype is associated with hypertriglyceridemia. [PMID 20657596]

[PMID 22399527] Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

[PMID 21889769] Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia

[PMID 22437554] Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.

[PMID 22567092] MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS

[PMID 19656773] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20160193] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

[PMID 20339536] Genome-wide association of lipid-lowering response to statins in combined study populations.

[PMID 20385826] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

[PMID 23119086] Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate

[PMID 23404648] An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease

[PMID 24623848] Genetic Variants Reflecting Higher Vitamin E Status in Men Are Associated with Reduced Risk of Prostate Cancer

[PMID 22914552] APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial.

[PMID 23832694] Common genetic variants associated with lipid profiles in a Chinese pediatric population.

[PMID 24989072] Association between the MLX interacting protein-like, BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels

[PMID 26405538] Association of FURIN and ZPR1 polymorphisms with metabolic syndrome

[PMID 26445370] Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status – The HUNT Study

More Information

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.7934
Latino/Admixed American	0.7028
Ashkenazi Jewish	0.7966
East Asian	0.7898
European	0.8624
Other (population not assigned)	0.8024

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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