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APOA5
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs758216033 | |||
| rs3135506 | |||
| rs761343549 | |||
| rs1409787509 | |||
| rs143292359 | |||
| rs148778842 | |||
| rs201201147 | |||
| rs2075291 | |||
| rs3135507 | |||
| rs34282181 | |||
| rs761948955 | |||
| rs765565265 | |||
| rs76753536 | |||
| rs781206581 | |||
| rs12287066 | |||
| rs1458624017 | |||
| rs662799 | |||
| rs61905078 | |||
| rs146000918 | |||
| rs148013820 |
Summary
APOA5 determines blood triglyceride levels and it is a component of lipoprotein fractions.
APOA5 is produced in the liver and secreted in the blood. It is associated with risk fo stroke and metabolic syndrome as well as obesity.
Protein names
Found in These Blog Articles
GHR Function
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
More Information
Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene. The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.
It is a component of several lipoprotein fractions including VLDL, HDL, chylomicrons. It is believed that apoA-V affects lipoprotein metabolism by interacting with LDL-R gene family receptors.
APOA5:
-
Regulates triglycerides in blood: when ApoA5 increases, the triglycerides are reduced and vice versa. Therefore, the deficiency of ApoA5 is associated with high levels of triglycerides in blood. [R]
-
Produced in liver and then secreted to the blood
-
Variations on ApoA5 have been reported to increase blood triglycerides. [R]
-
Correlated with hardening of the arteries in heart [R] and brain [R].
-
Risk of obesity development [R]
-
Associated with risk of stroke [R]
-
Genes show higher risk of metabolic syndrome in German and Austrian [R] Romanian [R] and Japanese [R] populations.
Lifestyle & Supplement Interactions
Fix: PPAR, LXR, HNF4, and USF1 that contribute to the regulation of APOA5 expression These are the best supplements for these pathways: Resveratrol + 15g Leucine , Nicotinamide Riboside – Niagen NAD , Cold (R), Exercise, Fasting, PQQ , Fish Oil/DHA (R),Cinnamon (R), Epidmedium
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