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SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
rs5215
Traits
| Trait | Variant | Impact | PMID | Author (year) |
|---|---|---|---|---|
| Type 2 diabetes [EA] | T |
|
Nat Genet | Zhao W (2017) |
| Body mass index | T |
|
Nat Genet | Akiyama M (2017) |
| "Diabetes, varying definitions" | T |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Other diabetes, wide definition" | T |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 2 diabetes, definitions combined" | T |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 2 diabetes, definitions combined, including avohilmo" | T |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 2 diabetes, strict (exclude DM1)" | T |
|
Unknown journal | FINNGEN_R5 (2021) |
| Circulating leptin levels or type 2 diabetes | T |
|
BMJ Open Diabetes Res Care | Wang X (2020) |
| Diabetes mellitus | T |
|
Unknown journal | FINNGEN_R5 (2021) |
| Psoriasis or type 2 diabetes (trans-disease meta-analysis) | T |
|
J Invest Dermatol | Patrick MT (2020) |
| Type 2 diabetes | T |
|
Nat Commun | Xue A (2018) |
| Type 2 diabetes (adjusted for BMI) | T |
|
Nat Genet | Mahajan A (2018) |
| Type 2 diabetes [DGI+FUSION+WTCCC] | T |
|
Science | Zeggini E (2007) |
| Type 2 diabetes with other specified/multiple/unspecified complications | T |
|
Unknown journal | FINNGEN_R5 (2021) |
Summary
The association between type-1 diabetes and rs5215 is mentioned as being replicated in [PMID 17554300]; there is also a 90% correlation between rs5215 and rs5219.
[PMID 20043145] Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study
[PMID 20802253] Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
[PMID 22569928] Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
[PMID 16733889] [Association analysis of 30 type 2 diabetes candidate genes in Chinese Han population].
[PMID 17786212] Heterogeneity in meta-analyses of genome-wide association investigations.
[PMID 18426861] Association analysis of type 2 diabetes Loci in type 1 diabetes.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 18591388] Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women’s Genome Health Study.
[PMID 19526209] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
[PMID 19931040] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
[PMID 20017978] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
[PMID 20018041] The effect of multiple genetic variants in predicting the risk of type 2 diabetes.
[PMID 20018066] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study.
[PMID 20144327] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
[PMID 20550665] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
[PMID 21573802] Association between KCNJ11 gene polymorphisms and risk of type 2 diabetes mellitus in East Asian populations: a meta-analysis in 42,573 individuals.
[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
[PMID 22438186] A SNP in G6PC2 predicts insulin secretion in type 1 diabetes
[PMID 25247988] Population Specific Impact of Genetic Variants in KCNJ11 Gene to Type 2 Diabetes: A Case-Control and Meta-Analysis Study
[PMID 25755232] Habitual coffee intake, genetic polymorphisms, and type 2 diabetes
More Information
rs5215 is a SNP in the KCNJ11 gene. It is associated with ß-cell dysfunction and hence a genetic marker for type 2 diabetes (T2D).
A lower risk of prediabetes and type 2 diabetes combined with coffee intake was seen among individuals with the CC genotype in East Asians [R].
Population Alleles Frequency
| ethhicity | frequency |
|---|---|
| African/African-American | 0.9132 |
| Latino/Admixed American | 0.6052 |
| Ashkenazi Jewish | 0.6552 |
| East Asian | 0.6372 |
| European | 0.6366 |
| Other (population not assigned) | 0.6103 |
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