rs2569190

[PMID 18727828] rs2569190(C) (frequency = 39%) increased stroke risk among smokers (OR = 2.05, 95% CI=1.09-3.86, p=0.03), but not among non-smokers (OR = 0.93, 95% CI=0.62-1.39, p=0.72)

[PMID 18417506] rs1295685 and rs20541 were significantly associated with elevated IgE levels in pooled analyses. rs2569190(T;T) and rs2569191(C;C) genotypes associated with lower IgE

A meta-analysis of 7 studies (comprising a total of 1488 patients and 1600 control subjects) found no significant association between rs2569190 and cerebrovascular diseases.[PMID 19433913]

[PMID 19701968] Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection

[PMID 19741468] Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation

[PMID 19830784] Association of CD14 variant with prostate cancer in African American men

[PMID 19968655] The role of lipopolysaccharide in the development of atopy in humans

[PMID 20109750] Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli

[PMID 22015088] CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 15867866] Polymorphisms in the 5′ region of the CD14 gene are associated with eczema in young children.

[PMID 16614348] Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment.

[PMID 16759385] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16846490] Lemierre’s syndrome and genetic polymorphisms: a case report.

[PMID 17062130] Polymorphisms within inflammatory genes and colorectal cancer.

[PMID 18987746] Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women’s Genome Health Study.

[PMID 19337058] CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19759553] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.

[PMID 20398919] CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?

[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

[PMID 21333644] C(-260)T polymorphism in the promoter of CD 14 gene is not associated with myocardial infarction in the Tunisian population.

[PMID 21389010] Endotoxin exposure, CD14 and wheeze among farmers: a gene–environment interaction.

[PMID 21596674] Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.

[PMID 21885391] Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.

[PMID 21996339] Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies.

[PMID 22376040] Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.

[PMID 22494793] Innate immunity gene single nucleotide polymorphisms and otitis media

[PMID 23741383] CD14 -159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis

[PMID 23349936] Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity

[PMID 24028589] TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk

[PMID 22749237] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.

[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 25394369] The Association of Polymorphisms of TLR4 and CD14 Genes with Susceptibility to Sepsis in a Chinese Population

[PMID 25000179] Genetic polymorphisms and sepsis in premature neonates

[PMID 25840711] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis

[PMID 26174031] TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis

[PMID 26462562] Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout

[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

[PMID 18727828] rs2569190(C) (frequency = 39%) increased stroke risk among smokers (OR = 2.05, 95% CI=1.09-3.86, p=0.03), but not among non-smokers (OR = 0.93, 95% CI=0.62-1.39, p=0.72)

[PMID 18417506] rs1295685 and rs20541 were significantly associated with elevated IgE levels in pooled analyses. rs2569190(T;T) and rs2569191(C;C) genotypes associated with lower IgE

A meta-analysis of 7 studies (comprising a total of 1488 patients and 1600 control subjects) found no significant association between rs2569190 and cerebrovascular diseases.[PMID 19433913]

[PMID 19701968] Endotoxin receptor CD14 gene variants and histological features in chronic HCV infection

[PMID 19741468] Impact of Polymorphisms of TLR4/CD14 and TLR3 on Acute Rejection in Kidney Transplantation

[PMID 19830784] Association of CD14 variant with prostate cancer in African American men

[PMID 19968655] The role of lipopolysaccharide in the development of atopy in humans

[PMID 20109750] Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli

[PMID 22015088] CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 15867866] Polymorphisms in the 5′ region of the CD14 gene are associated with eczema in young children.

[PMID 16614348] Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment.

[PMID 16759385] Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16846490] Lemierre’s syndrome and genetic polymorphisms: a case report.

[PMID 17062130] Polymorphisms within inflammatory genes and colorectal cancer.

[PMID 18987746] Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women’s Genome Health Study.

[PMID 19337058] CD14-159C/T and TLR9-1237T/C polymorphisms are not associated with gastric cancer risk in Caucasian populations.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19759553] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.

[PMID 20398919] CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation?

[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

[PMID 21333644] C(-260)T polymorphism in the promoter of CD 14 gene is not associated with myocardial infarction in the Tunisian population.

[PMID 21389010] Endotoxin exposure, CD14 and wheeze among farmers: a gene–environment interaction.

[PMID 21596674] Single nucleotide polymorphisms in the promoter of the gene encoding the lipopolysaccharide receptor CD14 are associated with bacterial diarrhea in US and Canadian travelers to Mexico.

[PMID 21885391] Respiratory health and endotoxin: associations and modification by CD14/-260 genotype.

[PMID 21996339] Opposite effects of allergy prevention depending on CD14 rs2569190 genotype in 3 intervention studies.

[PMID 22376040] Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.

[PMID 22494793] Innate immunity gene single nucleotide polymorphisms and otitis media

[PMID 23741383] CD14 -159 C>T Gene Polymorphism with Increased Risk of Tuberculosis: Evidence from a Meta-Analysis

[PMID 23349936] Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity

[PMID 24028589] TLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risk

[PMID 22749237] Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.

[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 25394369] The Association of Polymorphisms of TLR4 and CD14 Genes with Susceptibility to Sepsis in a Chinese Population

[PMID 25000179] Genetic polymorphisms and sepsis in premature neonates

[PMID 25840711] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis

[PMID 26174031] TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis

[PMID 26462562] Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout

[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease