rs243865

Chromosome : 16 , Position: 55477894

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: C

Alternative Alleles: T

Associated Genes

LPCAT2

SLC6A2

MMP2

CES1

CAPNS2

IRX6

MT4

MT1M

AKTIP

CES5A

GNAO1

Summary

[PMID 19454611] Matrix metalloproteinase-2 polymorphisms and breast cancer susceptibility

[PMID 20808730] Role of functional single nucleotide polymorphisms of MMP1, MMP2, and MMP9 in open angle glaucomas

[PMID 21228795] Impact of LIMK1, MMP2 and TNF-? variations for intracranial aneurysm in Japanese population

[PMID 21612407] Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2

[PMID 22621753] Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer

[PMID 21307882] Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients

[PMID 16356191] Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.

[PMID 17958893] Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression.

[PMID 18205826] The MMP2 rs243865-T allele is not a major genetic factor for rheumatoid arthritis in the French Caucasian population.

[PMID 18784838] Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.

[PMID 18787887] Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.

[PMID 18802702] Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms).

[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.

[PMID 19822020] Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

[PMID 20157405] Matrix Metallopeptidase 2 Gene Polymorphism is Associated with Obesity in Korean Population.

[PMID 20222942] Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke.

[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

[PMID 21161369] Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and breast cancer risk: a meta-analysis.

[PMID 21396799] Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw.

[PMID 22388798] Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.

[PMID 23257253] Expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in recurrent chronic rhinosinusitis with nasal polyposis

[PMID 23819551] Genetic polymorphisms in matrix metalloproteinases (MMPs) and tissue inhibitors of MPs (TIMPs), and bladder cancer susceptibility

[PMID 22710194] MMP13 polymorphism decreases risk for dental caries.

[PMID 23242659] Effect of metabolic syndrome risk factors and MMP-2 genetic variations on circulating MMP-2 levels in childhood obesity.

[PMID 26754027] Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population.

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