rs2242446

Chromosome : 16 , Position: 55656513

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: C

Alternative Alleles: T

Associated Genes

SLC6A2

LPCAT2

CAPNS2

CES1

MMP2

CES5A

IRX6

Summary

[PMID 20863575] Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD

[PMID 15722184] Norepinephrine transporter (NET) promoter and 5′-UTR polymorphisms: association analysis in panic disorder.

[PMID 17630229] Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups.

[PMID 18081710] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

[PMID 18779921] The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population.

[PMID 19693267] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

[PMID 21412203] Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.

[PMID 23442739] Psychomotor depressive symptoms may differentially respond to venlafaxine

[PMID 23648227] Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis.

[PMID 25990886] Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression

[PMID 26051731] Association study between 5-HT2A and NET gene polymorphisms and recurrent major depression disorder in Chinese han population

[PMID 26508020] Potential involvement of NET polymorphism in serotonin/norepinephrine reuptake inhibitor response in panic disorder

More Information

rs2242446 is linked to the SLC6A2 gene. It is significantly associated with major depression.

T/C polymorphism was found to be associated with panic disorder (p < 0.01) [R].

T/C was associated with recurrent depression (OR = 4.15) [R].

''C'' allele was associated with greater blood pressure (BP) response to exercise in humans [R].

''C'' allele carriers had smaller hippocampal volumes relative to other genotypes [R].

Panic disorder patients treated with Serotonin/norepinephrine reuptake inhibitor (SNRI) with only non-C carrier TT genotype showed significantly reduced Panic Disorder Severity Scale (PDSS) scores [R].

The "C" allele is associated with higher blood pressure whilst exercising [R].

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.8167
Latino/Admixed American	0.7624
Ashkenazi Jewish	0.7034
East Asian	0.6892
European	0.7135
Other (population not assigned)	0.7398

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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