rs2070874

This SNP is one of five SNPs reported to be useful in a SNP set defining the risk of dying from prostate cancer among patients with the disease; see gs242 and gs243.

[PMID 19254294] Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.

[PMID 19058298] Promoter polymorphisms of IL2, IL4, and risk of gastric cancer in a high-risk Chinese population

[PMID 20032229] Prediction of functional impairment and remission in rheumatoid arthritis patients by biochemical variables and genetic polymorphisms

[PMID 20332709] Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9 and IL-13 with Graves’ disease

[PMID 20921925] Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity

[PMID 22053598] Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population

[PMID 22377791] Association of genetic polymorphisms of interleukins with new-onset diabetes after transplantation in renal transplantation

[PMID 15570643] Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis.

[PMID 15660293] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 17303794] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 18056382] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.

[PMID 18454680] Genetic basis for adverse events after smallpox vaccination.

[PMID 18538381] Clinical and genetic risk factors of self-reported penicillin allergy.

[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18781131] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

[PMID 19840389] Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.

[PMID 20015396] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

[PMID 20525402] Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

[PMID 21387019] Differences in candidate gene association between European ancestry and African American asthmatic children.

[PMID 21501388] Association between interleukin-4 gene polymorphisms and intracerebral haemorrhage in Korean population.

[PMID 22528336] Association study of interleukin-4 polymorphisms with paranoid schizophrenia in the Polish population: a critical approach.

[PMID 23572437] Three common polymorphisms in the IL-4 gene and cancer risk: A meta-analysis involving 5,392 cases and 6,930 controls

[PMID 23651591] Association of polymorphisms in the interleukin-4 gene with response to hepatitis B vaccine and susceptibility to hepatitis B virus infection: a meta-analysis

[PMID 23654077] IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients

[PMID 23668806] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

[PMID 23924473] Association between the polymorphisms of interleukin-4, the interleukin-4 receptor gene and asthma

[PMID 23964553] Relationship between polymorphisms in IL4 and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

[PMID 24463336] Association of Interleukin-4 genetic polymorphisms with sporadic Alzheimer’s disease in Chinese Han population

[PMID 22573572] Phenotype-genotype profiles in Crohn’s disease predicted by genetic markers in autophagy-related genes (GOIA study II).

[PMID 22824342] Association of polymorphisms of cytokine and TLR-2 genes with long-term immunity to hepatitis B in children vaccinated early in life.

[PMID 22884982] Polymorphisms in the IL4 gene, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.

[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 23663310] Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.

[PMID 25295591] Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population

[PMID 25768087] An ADAM33 Polymorphism Associates with Progression of Preschool Wheeze into Childhood Asthma: A Prospective Case-Control Study with Replication in a Birth Cohort Study

[PMID 25785117] Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis

[PMID 26681045] Investigation of polymorphisms in anti-inflammatory cytokine genes in hematogenous osteomyelitis.

Heterozygous TC and combined TC/CC genotypes were associated with a significantly decreased gastric cancer risk (adjusted odds ratio (OR) = 0.81 for TC; OR = 0.83 for TC/CC, respectively) [R].

The ''T'' allele may be a risk factor for cancer development among Caucasians (A allele vs. G allele: OR = 1.18, P heterogeneity = 0.621, P = 0.0172; AA vs.AG/GG: OR = 1.23, P heterogeneity = 0.196, P = 0.024) [R].

The ''T'' allele was associated with high responses to hepatitis B vaccine [R].

Individuals who carried the ''C'' allele demonstrated increased asthma risk compared to TT homozygotes [R].

The ''T'' allele is associated with humoral response to hepatitis B vaccine after analyzed by multivariable logistic regression analysis (P=0.015) [R].

The CC genotype was observed to be significantly associated with chronic hepatitis B (CHB) in subgroup analysis in males CC versus TT (OR: 4.193, P = 0.037; and OR: 3.438, P = 0.044) and CC versus TT+CT (OR: 4.09, P = 0.038; and OR: 3.43, P = 0.042) [R].

The expression of the CC genotype or the ''C'' allele was a risk factor for hematogenous osteomyelitis (HO) development, with higher frequencies of CT and ''T'' being found in the control samples [R].