rs1927911

[PMID 23936790] Association of Toll-like receptor 4 polymorphisms with diabetic foot ulcers and application of artificial neural network in DFU risk assessment in type 2 diabetes patients

[PMID 19380025] The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men

[PMID 20685742] Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

[PMID 21081146] Impact of Toll-like receptor 4 polymorphisms on risk of cancer

[PMID 21921986] Toll-like receptor 4 gene polymorphisms do not associate with normal tension glaucoma in a Korean population

[PMID 22272615] Common variants in toll-like receptor 4 confer susceptibility to Alzheimer’s disease in a Han Chinese population

[PMID 22238472] Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease

[PMID 17699831] Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

[PMID 18298826] Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol.

[PMID 18396467] Genetic variation and haplotype structures of innate immunity genes in eastern India.

[PMID 18422738] Study of Toll-like receptor gene loci in sarcoidosis.

[PMID 18586872] Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma.

[PMID 19131814] Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study.

[PMID 19500628] Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis.

[PMID 19503741] Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

[PMID 19567509] Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.

[PMID 19586676] Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection.

[PMID 19753309] SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

[PMID 20011079] Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.

[PMID 20200442] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 20227302] Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.

[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 21403649] Association of polymorphisms in the TLR4 gene with the risk of developing neutropenia in children with leukemia.

[PMID 23084080] The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis

[PMID 23639307] Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study

[PMID 24365597] Polymorphisms of the TLR4 gene and risk of gastric cancer

[PMID 22525209] Common polymorphisms in TLR4 gene associated with susceptibility to pulmonary tuberculosis in the Sudanese.

[PMID 22831837] Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma.

[PMID 24929142] Genetic polymorphisms in the Toll-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer

[PMID 25216863] Association between Toll-like receptor 4 and interleukin 17 gene polymorphisms and colorectal cancer susceptibility in Northeast China

[PMID 25590839] TLR4 rs1927911, but Not TLR2 rs5743708, Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population: A Case-Control Study

[PMID 25840711] Interactions between innate immunity genes and early-life risk factors in allergic rhinitis

[PMID 25908385] Association of TLR4 gene polymorphisms with sporadic Parkinson’s disease in a Han Chinese population

[PMID 25947554] The association between toll-like receptor 4 polymorphisms and diabetic retinopathy in Chinese patients with type 2 diabetes

[PMID 25360682] Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis

The minor allele ''A'' was associated with a lower risk of myocardial infarction (MI) (odds ratio 0.88) [R].

GG genotype (ORadj=6.68) and the AG genotype (ORadj=2.73) increased the risk of prostate cancer (PC) [R]. 

AA genotype influences the susceptibility to adverse effects of traffic-related air pollution on childhood asthma (OR 4.4) [R]. 

Women with pelvic inflammatory disease (PID) who carried the GG genotype had significantly increased odds of C. trachomatis (OR, 3.7; P = .002) [R]. 

Individuals with the minor allele ''A'' had a 1.47- to 1.65-fold increased risk of normal tension glaucoma (NTG) [R].

Carriers of at least 1 minor allele ''A'' were consistently at an increased risk of developing allergic rhinitis (OR=1.24) [R].

Individuals carrying the AA genotype had a significantly decreased risk of gastric cancer (GC) (OR=0.37, P=0.001), compared with the GG genotype [R].

Significantly increased frequencies of the GG genotype and the ''G'' allele were observed in patients with type 2 diabetes 
[R].