rs189037

Chromosome : 11 , Position: 108223106

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: A

Associated Genes

ATM

NPAT

ACAT1

C11ORF65

POGLUT3

EXPH5

DDX10

CWF19L2

CUL5

ZC3H12C

ALKBH8

RAB39A

SLC35F2

Summary

[PMID 19193393] reduced cytokinesis-block micronucleus (CBMN) frequency among workers exposed to polycyclic aromatic hydrocarbons

rs600931(G;G)
rs189037(G;G)
rs624366(G;G)
rs227092(G;G)

[PMID 21187516] Association between Ataxia Telangiectasia Mutated Gene Polymorphisms and Breast Cancer in Taiwanese Females

[PMID 21739480] Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: A pathway-based analysis

[PMID 22126766] [Association between single nucleotide polymorphism locus rs189037 in the promoter of ATM gene and nasopharyngeal carcinoma susceptibility in Cantonese]

[PMID 21050672] Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy

[PMID 22229509] Association between Ataxia Telangiectasia Mutated Gene Polymorphisms and Childhood Leukemia in Taiwan

[PMID 22438227] Functional Variations in the ATM Gene and Susceptibility to Differentiated Thyroid Carcinoma

[PMID 17428325] Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.

[PMID 20004998] ATM polymorphisms and risk of lung cancer among never smokers.

[PMID 20816691] A functional single nucleotide polymorphism in promoter of ATM is associated with longevity.

[PMID 21108427] Association between DNA repair gene ATM polymorphisms and oral cancer susceptibility.

[PMID 21937043] Functional polymorphism rs189037 in the promoter region of ATM gene is associated with angiographically characterized coronary stenosis.

[PMID 23925578] Association of the ATM gene polymorphisms with papillary thyroid cancer

[PMID 24023351] Effects of Ataxia Telangiectasia Mutated (ATM) Genotypes and Smoking Habits on Lung Cancer Risk in Taiwan

[PMID 22960875] Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians.

[PMID 23154078] ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.

[PMID 25196645] Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma

[PMID 25759145] ATM Gene Single-Nucleotide Polymorphisms Predict Regimen-Related Gastrointestinal Toxicity in Patients Allografted after Reduced Conditionings

[PMID 26504743] ATM rs189037 (G>A) polymorphism and risk of lung cancer and head and neck cancer: A meta-analysis

[PMID 26629166] Single-nucleotide polymorphisms of TGFŒ≤1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China.

More Information

Incomplete

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.2762
Latino/Admixed American	0.6454
Ashkenazi Jewish	0.6241
East Asian	0.4093
European	0.5648
Other (population not assigned)	0.5755

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

Unlock Personalized Results And So Much More!

Shipping Worldwide

30-Days Money-Back Guarantee*

HSA/FSA Eligible

Essential Bundle

SelfDecode DNA Kit

24/7 AI Health Coach
1250+ Comprehensive DNA Health Reports
Personalized Diet, Supplement, & Lifestyle Recommendations
Lifestyle Risk Assessments
Unlimited access to Labs Analyzer

$418

$376

Men's Health Month 10% Off

Essential

Bundle

Everything in essential
SelfDecode DNA Kit
Methylation Pathway
+130 Medical Reports
25+ Longevity Screener Risk Assessments

Odds ratios to evaluate your risk for 25+ medical conditions
10-year risk scores to prioritize health conditions
Lifetime risk scores to plan for long-term health

$667

$566

Men's Health Month 15% Off

Men's Health Month 30% Off

Ultimate Bundle

Everything in essential+
SelfDecode DNA Kit
Medication Check (PGx testing) for 50+ medications
40+ Family Planning (Carrier Status) Reports
Ancestry Percentages
Mitochondrial Ancestry

$894

$625

* SelfDecode DNA kits are non-refundable. If you choose to cancel your plan within 30 days you will not be refunded the cost of the kit.

We will never share your data

We follow HIPAA and GDPR policies

We have World-Class Encryption & Security

People Love Us

Rated 4.7/5 from 750+ reviews

People Trust Us

200,000+ users, 2,000+ doctors & 80+ businesses

SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.

Policies

About

Support
Our Team
Affiliate Program
Privacy
Media