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rs1800779

Chromosome : 7 , Position: 150992855

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: A

Associated Genes

NOS3

KCNH2

TMEM176A

TMEM176B

ABCB8

AOC1

ASIC3

ATG9B

CDK5

GIMAP5

SLC4A2

AGAP3

FASTK

TMUB1

CHPF2

GBX1

ASB10

H2BE1

IQCA1L

REPIN1

ZNF775

ABCF2

ABCF2-H2BE1

GIMAP1

GIMAP1-GIMAP5

GIMAP2

SMARCD3

GIMAP4

GIMAP6

NUB1

GIMAP7

WDR86

CRYGN

GIMAP8

Traits

Trait	Variant	Impact	PMID	Author (year)
Forced expiratory volume in 1-second (fev1), predicted	A		Unknown journal	UKB Neale v2 (2018)

Summary

[PMID 19815736] The Relation between Endothelial Nitric Oxide Synthase Gene Variants and Primary Open-Angle Glaucoma: Interactions with Gender and Postmenopausal Hormone Use

[PMID 20409549] NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids

[PMID 21122033] Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients

[PMID 21291465] The association of genetic polymorphisms with cerebral palsy: a meta-analysis

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 18069999] Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study.

[PMID 18246059] Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure.

[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.

[PMID 18687083] Lack of association of endothelial nitric oxide synthase polymorphisms and migraine.

[PMID 18698212] Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women’s Genome Health Study.

[PMID 19493349] 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19584173] Kininogen gene (KNG) variation has a consistent effect on aldosterone response to antihypertensive drug therapy: the GERA study.

[PMID 20031567] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women’s Genome Health Study.

[PMID 21674837] Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy.

[PMID 24192154] Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease

[PMID 23826716] Association analysis of nitric oxide synthases: NOS1, NOS2A and NOS3 genes, with multiple sclerosis.

[PMID 25140814] Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy

More Information

Mechanism:

Decreases expression of Nitric Oxide Synthase 3 (G) [R]

The Minor "G" allele is associated with:

Susceptibility to Multiple Sclerosis in G-G individuals [R], based on a study of Kuwaiti subjects.
Greater risk of heart failure, in patients with hypertension. Individuals with the G allele have a 10% higher Hazard ratio than A-A individuals [R].
More accurate “social memory”, defined as facial and vocal recognition [R]. In a second validation study, this effect was only seen in men.
Higher risk of Cardioembolic Stroke in GG individuals [R]
Higher risk of Leukoaraiosis, or abnormalities of the white matter found in the brain, in Ischemic stroke patients with the GG genotype [R]. Among individuals with leukoaraiosis, the GG genotype also correlated with the greater extent of the disorder.
Greater risk for High tension Primary-open-angle- Glaucoma, in women [R].
Better lung function . Individuals with at least one G allele had higher FEV1, were able to expel more air in one forced breath, than A-A individuals [R].
Higher risk of chronic obstructive pulmonary disease (COPD) [R].

The Major "A" allele is associated with:

Poorer lung function in A-A individuals, compared to carriers of the G allele [R].

Haplotypes:

T/G/T at SNPs rs1800783/rs1800779/rs2070744: Greater risk of Hypoxic-Ischemic Encephalopathy (HIE), a neurological disorder affecting infants [R,R2].

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.8506
Latino/Admixed American	0.7417
Ashkenazi Jewish	0.6552
East Asian	0.8874
European	0.6336
Other (population not assigned)	0.6906

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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rs1800779

Associated Genes

Traits

Summary

More Information

Population Alleles Frequency

Frequently Asked Questions

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Limited time offer 25% off

Ultimate Bundle

Policies

About

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Health reports