rs1421085

Chromosome : 16 , Position: 53767042

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: T

Alternative Alleles: C

Associated Genes

FTO

RPGRIP1L

IRX5

AKTIP

RBL2

IRX3

Traits

Trait	Variant	PMID	Author (year)
Alcohol use disorder	C	Nat Commun	Kranzler HR (2019)
Whole body fat-free mass	C	Unknown journal	UKB Neale v2 (2018)
Pulse pressure [East Asian]	C	Nat Commun	Takeuchi F (2018)
Whole body water mass	C	Unknown journal	UKB Neale v2 (2018)
Trunk fat-free mass	C	Unknown journal	UKB Neale v2 (2018)
Trunk predicted mass	C	Unknown journal	UKB Neale v2 (2018)
Age at adiposity rebound	C	Sci Adv	Couto Alves A (2019)
Type 2 diabetes	C	Nat Genet	Vujkovic M (2020)
circulating leptin levels	C	Diabetes	Yaghootkar H (2020)
Dietary macronutrient intake [Protein]	C	Am J Clin Nutr	Tanaka T (2013)
Leg lean mass	C	Mol Genet Genomics	Zhang YX (2020)
Childhood body mass index	C	Hum Mol Genet	Felix JF (2015)
Comparative body size at age 10	C	Unknown journal	UKB Neale v2 (2018)
Body size at age 10	C	BMJ	Richardson TG (2020)
Medication use (HMG CoA reductase inhibitors)	C	Nat Commun	Wu Y (2019)
Age when periods started (menarche)	C	Unknown journal	UKB Neale v2 (2018)
Appendicular lean mass	C	Commun Biol	Pei YF (2020)
Arm fat-free mass (left)	C	Unknown journal	UKB Neale v2 (2018)
Arm predicted mass (left)	C	Unknown journal	UKB Neale v2 (2018)
Arm fat-free mass (right)	C	Unknown journal	UKB Neale v2 (2018)
Arm predicted mass (right)	C	Unknown journal	UKB Neale v2 (2018)
Morningness	C	Nat Genet	Jansen PR (2019)
Morning/evening person (chronotype)	C	Unknown journal	UKB Neale v2 (2018)
Alcohol intake frequency.	C	Unknown journal	UKB Neale v2 (2018)
Fasting insulin	C	Nat Commun	Lagou V (2021)
Problematic alcohol use (MTAG)	C	Nat Neurosci	Zhou H (2020)
Body mass index	C	Int J Obes (Lond)	Gong J (2017)
Water intake	C	Unknown journal	UKB Neale v2 (2018)
Average weekly beer plus cider intake	C	Unknown journal	UKB Neale v2 (2018)
Variation in diet	C	Unknown journal	UKB Neale v2 (2018)
Alcohol consumption	C	Nat Hum Behav	Evangelou E (2019)
Sex hormone-binding globulin levels adjusted for BMI	C	Nat Med	Ruth KS (2020)
Hand grip strength	C	Sci Rep	Tikkanen E (2018)
High light scatter reticulocyte count	C	Unknown journal	UKB Neale v2 (2018)
Abdominal subcutaneous adipose tissue volume	C	Elife	Liu Y (2021)
Basal metabolic rate	C	Sci Adv	Wang H (2019)
Basal metabolic rate variance	C	Sci Adv	Wang H (2019)
Body fat percentage	C	Am J Med Genet B Neuropsychiatr Genet	Hubel C (2018)
Body fat percentage [female]	C	Am J Med Genet B Neuropsychiatr Genet	Hubel C (2018)
Body fat percentage [male]	C	Am J Med Genet B Neuropsychiatr Genet	Hubel C (2018)
Bone mineral density or leg lean mass (pleiotropy)	C	Mol Genet Genomics	Zhang YX (2020)
Childhood body fatness	C	Obesity (Silver Spring)	Warner ET (2021)
Chronotype	C	Nat Commun	Jones SE (2019)
Diabetes diagnosed by doctor	C	Unknown journal	UKB Neale v2 (2018)
Diabetes \| non-cancer illness code, self-reported	C	Unknown journal	UKB Neale v2 (2018)
Fat-free mass	C	Am J Med Genet B Neuropsychiatr Genet	Hubel C (2018)
Fat-free mass [female]	C	Am J Med Genet B Neuropsychiatr Genet	Hubel C (2018)
Fat-free mass [male]	C	Am J Med Genet B Neuropsychiatr Genet	Hubel C (2018)
Hip circumference	C	Sci Adv	Wang H (2019)
Hip circumference variance	C	Sci Adv	Wang H (2019)
Metformin \| treatment/medication code	C	Unknown journal	UKB Neale v2 (2018)
Morning person	C	Nat Commun	Jones SE (2019)
No \| major dietary changes in the last 5 years	C	Unknown journal	UKB Neale v2 (2018)
Obesity	C	Nat Genet	Meyre D (2009)
Obesity (early onset extreme)	C	Nat Genet	Wheeler E (2013)
Obesity [Obesity class III]	C	Nat Genet	Berndt SI (2013)
Obesity [adults]	C	Nat Genet	Meyre D (2009)
Obesity [children]	C	Nat Genet	Meyre D (2009)
Preeclampsia (maternal genotype effect)	C	Nat Commun	Steinthorsdottir V (2020)
Relative fat intake	C	Mol Psychiatry	Meddens SFW (2020)
Simvastatin \| treatment/medication code	C	Unknown journal	UKB Neale v2 (2018)
Type 2 diabetes [Japanese]	C	Nat Commun	Imamura M (2016)
Waist circumference	C	Sci Adv	Wang H (2019)
Waist circumference variance	C	Sci Adv	Wang H (2019)
White \| bread type	C	Unknown journal	UKB Neale v2 (2018)
Wholemeal or wholegrain \| bread type	C	Unknown journal	UKB Neale v2 (2018)

Summary

CC ~1.7x increased obesity risk
CT ~1.3x increased obesity risk
TT normal obesity risk

More Information

The Minor "C" allele is associated with:

CC ~1.7x increased obesity risk.
CT ~1.3x increased obesity risk.

The Major "T" allele is associated with:

TT normal obesity risk.

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.1002
Latino/Admixed American	0.2299
Ashkenazi Jewish	0.5207
East Asian	0.1314
European	0.431
Other (population not assigned)	0.3729

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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