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SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
IRX3
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs112114803 | |||
| rs200236146 | |||
| rs202000036 | |||
| rs534542206 | |||
| rs142080873 | |||
| rs766444262 | |||
| rs1126960 | |||
| rs1162360349 | |||
| rs1199377918 | |||
| rs1269194191 | |||
| rs138097550 | |||
| rs1392088062 | |||
| rs1450355 | |||
| rs199931909 | |||
| rs200017055 | |||
| rs200154451 | |||
| rs538043692 | |||
| rs556340325 | |||
| rs557397597 | |||
| rs61744547 |
Summary
The IRX3 gene encodes Iroquois homeobox 3, a protein known mainly for its role in the development of the nervous system [R].
Some research suggests that IRX3 may prevent the development of tumor cells. In one study of women who underwent surgery for breast cancer, those who died within 5 years after the surgery had significantly lower IRX3 expression compared to those who survived for longer. The mechanism for this protective effect is unknown [R, R].
One variant in IRX3 has been associated with relative incidence of melanoma. Oddly, this variant also alters the expression of FTO, a gene that regulates weight gain and strongly affects susceptibility to obesity [R, R].
Researchers have investigated whether the FTO gene might have a functional effect on melanoma. However, there is no obvious reason that a gene known for affecting weight gain would also affect melanoma [R].
Protein names
Found in These Blog Articles
More Information
Lifestyle & Supplement Interactions
IRX3 encodes Iroquois homeobox 3. Variants of IRX3 may play a role in melanoma by disrupting tumor suppressor activities. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by directly increasing IRX3 or addressing downstream effects of low IRX3 levels.
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