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rs1295686

Chromosome : 5 , Position: 132660151

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: T

Alternative Alleles: C

Associated Genes

SLC22A5

SLC22A4

IL13

SOWAHA

IL4

KIF3A

CCNI2

IL5

LEAP2

RAD50

IRF1

SEPTIN8

SHROOM1

GDF9

UQCRQ

AFF4

HSPA4

P4HA2

ZCCHC10

PDLIM4

Traits

Trait	Variant	PMID	Author (year)
Lymphocyte counts	C	Cell	Chen MH (2020)
Allergy	C	Nat Genet	Pickrell JK (2016)
Asthma (adult onset)	C	Am J Hum Genet	Ferreira MAR (2019)
Asthma (childhood onset)	C	Am J Hum Genet	Ferreira MAR (2019)
Atopic dermatitis	C	Am J Hum Genet	Baurecht H (2015)

Summary

[PMID 21050946] Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE

[PMID 22515947] Associations Between Pro- and Anti-Inflammatory Cytokine Genes and Breast Pain in Women Prior to Breast Cancer Surgery

[PMID 22075330] A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study

[PMID 15660293] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 17303794] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

[PMID 17346294] IL13 gene polymorphism association with cord serum immunoglobulin E.

[PMID 18056382] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.

[PMID 18186920] IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.

[PMID 18410415] Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.

[PMID 18625055] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women’s Genome Health Study.

[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19956101] Overview of the Rapid Response data.

[PMID 19956102] Evidence for association of the TCF7 locus with type I diabetes.

[PMID 19956109] The Type I Diabetes Genetics Consortium ‘Rapid Response’ family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20015396] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

[PMID 20403202] Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study.

[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.

[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

[PMID 23841068] Interleukin-13 +1923C/T Polymorphism Is Associated with Asthma Risk: A Meta-Analysis

[PMID 23028483] Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.

[PMID 26365633] Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.3436
Latino/Admixed American	0.5213
Ashkenazi Jewish	0.7063
East Asian	0.6609
European	0.7591
Other (population not assigned)	0.6878

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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rs1295686

Associated Genes

Traits

Summary

Population Alleles Frequency

Frequently Asked Questions

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Limited time offer 25% off

Ultimate Bundle

Policies

About

Navigation

Health reports