High Blood Sugar
Anxiety
Gluten Sensitivity
Gut Inflammation
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IBS
Mood
Insomnia
PTSD
Mood Swings
Overweight
Memory Performance
Sexual Dysfunction
PCOS
Psoriasis
Joint Pain
Attention/ADHD
Chronic Fatigue / Tiredness
Allergies
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Acne
Tinnitus
Eczema
Food Allergy
Vitamin B6
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Restless Leg Syndrome
Grinding Teeth
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Magnesium
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Heart Health
Migraines
(High) Cholesterol
Headache
Chronic Pain
Back pain
Shoulder & Neck Pain
Stress
Inflammation
Omega-3 needs
Salt Sensitivity
Endurance
Power performance
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Exercise recovery
Brain Fog
Female Fertility
Longevity
Addiction
Erectile Dysfunction
Male Infertility
MTHFR
Joint Inflammation
GERD
Ulcers
Sleep Apnea
Periodontitis
Varicose Veins
H. pylori
Liver Health
Canker Sores
Gallstones
Kidney Health
Gout
Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
Hemorrhoids
Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
Cannabis addiction
Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
Salicylate Sensitivity
Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps
rs102275
Chromosome
: 11 , Position: 61790331
Most conditions are affected by anywhere from hundreds to millions of
genetic variants (SNPs). A single SNP usually has a minor contribution to
a person’s overall genetic risk for a certain condition. That is why you
shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to
determine polygenic risk scores (PRSs), which are the basis of most health
reports.
Reference Allele: T
Alternative Alleles:
C
Traits
| Trait | Variant | Impact | PMID | Author (year) |
|---|---|---|---|---|
| Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) [Conditioned on rs174547] | C |
|
Circ Cardiovasc Genet | Guan W (2014) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:3/Phosphatidylcholine with diacyl residue sum C36:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Lysophosphatidylcholine with acyl residue C20:3/Lysophosphatidylcholine with acyl residue C20:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C38:3/Phosphatidylcholine with diacyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C36:3/Phosphatidylcholine with acyl-alkyl residue sum C36:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C36:3/Phosphatidylcholine with acyl-alkyl residue sum C38:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:3/Lysophosphatidylcholine with acyl residue C20:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C36:3/Phosphatidylcholine with acyl-alkyl residue sum C36:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C38:3/Phosphatidylcholine with diacyl residue sum C40:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C34:1/Phosphatidylcholine with diacyl residue sum C36:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C36:3/Phosphatidylcholine with acyl-alkyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:3/Phosphatidylcholine with acyl-alkyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:4/Phosphatidylcholine with acyl-alkyl residue sum C36:3] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C34:1/Phosphatidylcholine with diacyl residue sum C38:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite concentrations in chronic kidney disease [Lysophosphatidylcholine with acyl residue C20:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:1/Phosphatidylcholine with diacyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C38:5/Phosphatidylcholine with acyl-alkyl residue sum C36:3] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C34:3/Phosphatidylcholine with diacyl residue sum C36:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C34:3/Phosphatidylcholine with diacyl residue sum C38:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C38:4/Phosphatidylcholine with acyl-alkyl residue sum C36:3] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C36:2/Phosphatidylcholine with acyl-alkyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C34:2/Phosphatidylcholine with acyl-alkyl residue sum C36:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C34:1/Phosphatidylcholine with diacyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:4/Sphingomyelin with acyl residue sum C24:0] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C38:4/Sphingomyelin with acyl residue sum C24:0] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:3/Phosphatidylcholine with acyl-alkyl residue sum C36:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C34:3/Phosphatidylcholine with acyl-alkyl residue sum C36:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C36:5/Sphingomyelin with acyl residue sum C24:0] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C34:2/Phosphatidylcholine with acyl-alkyl residue sum C38:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C38:3/Phosphatidylcholine with acyl-alkyl residue sum C40:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C38:5/Sphingomyelin with acyl residue sum C24:0] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C38:3/Phosphatidylcholine with acyl-alkyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite concentrations in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C36:5/Sphingomyelin with acyl residue sum C24:1] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C34:2/Phosphatidylcholine with acyl-alkyl residue sum C36:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C34:2/Phosphatidylcholine with acyl-alkyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C38:4/Phosphatidylcholine with acyl-alkyl residue sum C44:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:5/Phosphatidylcholine with diacyl residue sum C36:6] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C38:5/Phosphatidylcholine with acyl-alkyl residue sum C44:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C34:2/Phosphatidylcholine with diacyl residue sum C40:5] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C36:1/Phosphatidylcholine with acyl-alkyl residue sum C38:4] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with acyl-alkyl residue sum C38:4/Sphingomyelin with acyl residue sum C24:0] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Serum metabolite ratios in chronic kidney disease [Phosphatidylcholine with diacyl residue sum C32:0/Phosphatidylcholine with diacyl residue sum C34:3] | C |
|
J Am Soc Nephrol | Li Y (2018) |
| Phosphatidylcholine levels [PC(16:1;0-18:2;0] | C |
|
Nat Commun | Tabassum R (2019) |
| Oleic acid (18:1n-9) levels [EA] | C |
|
J Lipid Res | Hu Y (2017) |
| Oleic acid (18:1n-9) levels | C |
|
J Lipid Res | Hu Y (2017) |
| Oleic acid (18:1n-9) levels [Chinese] | C |
|
J Lipid Res | Hu Y (2017) |
| Stearic acid (18:0) levels | C |
|
Circ Cardiovasc Genet | Wu JH (2013) |
| Glycerophospholipid levels [Phosphatidylcholine acyl-alkyl C38:4] | C |
|
Nat Commun | Draisma HHM (2015) |
| Glycerophospholipid levels [Phosphatidylcholine diacyl C40:4] | C |
|
Nat Commun | Draisma HHM (2015) |
| Glycerophospholipid levels [Phosphatidylcholine acyl-alkyl C44:6] | C |
|
Nat Commun | Draisma HHM (2015) |
| Glycerophospholipid levels [Phosphatidylcholine acyl-alkyl C40:4] | C |
|
Nat Commun | Draisma HHM (2015) |
| Glycerophospholipid levels [Phosphatidylcholine acyl-alkyl C44:5] | C |
|
Nat Commun | Draisma HHM (2015) |
| Glycerophospholipid levels [Phosphatidylcholine diacyl C42:4] | C |
|
Nat Commun | Draisma HHM (2015) |
| Glycerophospholipid levels [Phosphatidylcholine acyl-alkyl C40:5] | C |
|
Nat Commun | Draisma HHM (2015) |
| Glycerophospholipid levels [Phosphatidylcholine acyl-alkyl C42:5] | C |
|
Nat Commun | Draisma HHM (2015) |
| Eosinophill percentage | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Red blood cell count | C |
|
Cell | Chen MH (2020) |
| Palmitoleic acid (16:1n-7) levels | C |
|
J Lipid Res | Hu Y (2017) |
| Reticulocyte count | C |
|
Cell | Vuckovic D (2020) |
| Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) | C |
|
PLoS Genet | Lemaitre RN (2011) |
| Eosinophill count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| High light scatter reticulocyte count | C |
|
Cell | Vuckovic D (2020) |
| Average weekly champagne plus white wine intake | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Irritable mood | C |
|
Nat Commun | Nagel M (2018) |
| Bipolar disorder or major depressive disorder | C |
|
Biol Psychiatry | Coleman JRI (2019) |
| Crohn's disease | C |
|
Nat Genet | Franke A (2010) |
| Crohn's disease [EA] | C |
|
Nat Genet | Liu JZ (2015) |
| Metabolite levels | C |
|
PLoS Genet | Inouye M (2012) |
| Metabolite levels [PC 36:4] | C |
|
Cell Metab | Rhee EP (2013) |
| Phospholipid levels (plasma) [levels] | C |
|
PLoS Genet | Demirkan A (2012) |
| Serum metabolite levels (CMS) [MUFA] | C |
|
Nat Commun | Gallois A (2019) |
| Serum metabolite levels (CMS) [MUFA_FA] | C |
|
Nat Commun | Gallois A (2019) |
| Serum metabolite levels [MUFA_FA] | C |
|
Nat Commun | Gallois A (2019) |
Summary
[PMID 19060906] Common variants at 30 loci contribute to polygenic dyslipidemia.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19750004] A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.
[PMID 19798445] Genetic determinants of circulating sphingolipid concentrations in European populations.
Population Alleles Frequency
| ethhicity | frequency |
|---|---|
| African/African-American | 0.6634 |
| Latino/Admixed American | 0.6564 |
| Ashkenazi Jewish | 0.3472 |
| East Asian | 0.579 |
| European | 0.3501 |
| Other (population not assigned) | 0.4044 |
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