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rs1018381

Chromosome : 6 , Position: 15656839

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: A, T, C

Associated Genes

DTNBP1

JARID2

MYLIP

Summary

g2b2mh blog In a population of healthy individuals, those that carry common variants (such as rs760761, rs1018381, rs2619522) located in the dysbindin (DTNBP1) gene, a risk factor for schizophrenia, show minor cognitive impairments such as decreased attentional capacity, worse performance on memory tasks, and alterations in schizotypal beliefs and experiences.

[PMID 19335929] Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects.

[PMID 19497374] Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals

[PMID 19077176] Variation in the dysbindin gene and normal cognitive function in three independent population samples

[PMID 19621369] The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval

[PMID 19650139] Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals

[PMID 20846375] The effects of a DTNBP1 gene variant on attention networks: an fMRI study

[PMID 21130223] Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability

[PMID 12098102] Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.

[PMID 12474144] Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.

[PMID 14618545] The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease.

[PMID 15290652] A powerful strategy to account for multiple testing in the context of haplotype analysis.

[PMID 15362017] Association of the DTNBP1 locus with schizophrenia in a U.S. population.

[PMID 17033966] Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.

[PMID 17074466] DTNBP1 genotype influences cognitive decline in schizophrenia.

[PMID 17445278] Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.

[PMID 18663367] The dystrobrevin-binding protein 1 gene: features and networks.

[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.

[PMID 18797396] Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression.

[PMID 18804346] Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.

[PMID 19369910] The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.

[PMID 19862852] Association study of DTNBP1 with schizophrenia in a US sample.

[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

[PMID 22019876] The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: a TBSS-based diffusion tensor imaging study.

[PMID 22580710] The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.

[PMID 22911901] Association of genetic variations in DTNBP1 with cognitive function in schizophrenia patients and healthy subjects.

More Information

rs1018381 is a SNP of the DTNBP1 gene. It significantly influences the general cognitive ability and personality traits [R].

Healthy subjects with the risk allele ''A'' had significantly lower scores on the Schizotypal Personality Questionnaire – Brief Version (SPQ-B) (p=0.0005) and the Interpersonal Deficit subscale (p=0.0005) [R].

The minor allele ''A'' carriers had lower cognitive ability scores than the major allele ''G'' homozygotes (GG) [R].

Carriers of the minor allele ''A'' may have an increased risk for schizophrenia due to altered fiber tracts compared to homozygote carriers of the major allele ''G'' [R].

Population Alleles Frequency

ethhicity frequency	A	T	C
African/African-American	0.3272	–	–
Latino/Admixed American	0.1498	–	–
Ashkenazi Jewish	0.1103	–	–
East Asian	0.0783	–	–
European	0.07	–	–
Other (population not assigned)	0.0855	–	–

Frequently Asked Questions

Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation Why Are Alleles for This SNP Different Elsewhere?

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rs1018381

Associated Genes

Summary

More Information

Population Alleles Frequency

Frequently Asked Questions

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Ultimate Bundle

Limited Time Offer 25% Off

Individual DNA Reports

Methylation Pathway - MTHFR Test

Histamine Intolerance DNA Pathway Report

Gut Health, Digestion & IBS DNA Report

Autoimmune Disease Risk & Prevention DNA Report

See all reports

Policies

About

Navigation

Health reports