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TRAF1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs2239657 | |||
| rs10739581 | |||
| rs112678167 | |||
| rs1262234465 | |||
| rs881375 | |||
| rs2233757 | |||
| rs10435843 | |||
| rs10435844 | |||
| rs10739577 | |||
| rs10818485 | |||
| rs10818486 | |||
| rs10985087 | |||
| rs12115312 | |||
| rs1930785 | |||
| rs2109895 | |||
| rs2159778 | |||
| rs2239658 | |||
| rs2241003 | |||
| rs2416804 | |||
| rs2416805 |
Find on This Page
Summary
The TRAF1 gene codes for part of a protein that interacts with protein A20 in order to suppress inflammation. Variants of TRAF1 may play a role in rheumatoid arthritis by dysregulating the production of TRAF1.
Supplement modifications may counteract the effects of these variants by increasing A20 production or activity.
Protein names
Found in These Blog Articles
More Information
Tumor necrosis factor (TNF) is a pro-inflammatory protein that has been suggested to play a major role in rheumatoid arthritis progression. This may be due to its ability to activate NF-kB [R].
NF-kB may stimulate the release of inflammatory proteins, as well as promote the formation of antibodies that recognize the body’s own tissues (autoantibodies) [R, R].
The TRAF1 gene codes for tumor necrosis factor receptor-associated factor 1 (TRAF1), part of a protein that may interact with A20 in order to suppress TNF activity and prevent NF-kB activation [R, R, R].
Although this implies that a low amount of TRAF1 may result in inflammation, high amounts of TRAF1 have also been linked to inflammation — suggesting that TRAF1 dysregulation can have deleterious effects [R].
Variants of TRAF1 have been associated with rheumatoid arthritis. These variants may dysregulate the production of TRAF1, which may lead to excess NF-kB production, inflammatory protein release, and autoantibody formation [R, R, R, R].
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