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TNFSF9
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs112025865 | |||
| rs1314688167 | |||
| rs184642529 | |||
| rs199772971 | |||
| rs199791725 | |||
| rs2234174 | |||
| rs2234175 | |||
| rs2234180 | |||
| rs34989544 | |||
| rs374312384 | |||
| rs531878264 | |||
| rs536154845 | |||
| rs544328145 | |||
| rs548530723 | |||
| rs61750000 | |||
| rs751241412 | |||
| rs752027230 | |||
| rs77313944 | |||
| rs112136162 | |||
| rs344586 |
Find on This Page
Summary
The TNFSF9 gene (tumor necrosis factor superfamily member 9) codes for a receptor protein called TNFSF9 — also known as “CD137” or “4-1BB” — which is expressed by various types of cells that make up your immune system [R, R, R].
In general, TNFSF9 receptors put your immune system on alert whenever your body detects a problem, such as a bacterial or viral infection [R, R, R], DNA damage [R], or the presence of tumor cells [R, R].
This, in turn, causes a variety of immune system cells to flood into the infected or damaged area, resulting in inflammation [R, R, R].
Additionally, TNFSF9 receptors activate a number of other inflammation-related mechanisms, such as NF-kB [R, R, R] and the JNK and MAPK signaling pathways [R, R]. It also stimulates the production of pro-inflammatory compounds called cytokines, such as interleukin 6 (IL-6) [R, R].
Therefore, this gene plays a very extensive role in triggering inflammation throughout your entire body.
SNPs in this gene, such as rs348373, have been associated with cognitive function — likely because it influences how vulnerable your brain is to chronic inflammation, which can have a significant impact on your overall cognitive ability [R, R, R].
To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on TNFSF9!
>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.
Protein names
Found in These Blog Articles
More Information
The TNFSF9 gene (tumor necrosis factor superfamily member 9) codes for a receptor protein called TNFSF9 — also known as “CD137” or “4-1BB” — which is expressed by various types of cells that make up your immune system [R, R, R].
In general, TNFSF9 receptors put your immune system on alert whenever your body detects a problem, such as a bacterial or viral infection [R, R, R], DNA damage [R], or the presence of tumor cells [R, R].
This, in turn, causes a variety of immune system cells to flood into the infected or damaged area, resulting in inflammation [R, R, R].
Additionally, TNFSF9 receptors activate a number of other inflammation-related mechanisms, such as NF-kB [R, R, R] and the JNK and MAPK signaling pathways [R, R]. It also stimulates the production of pro-inflammatory compounds called cytokines, such as interleukin 6 (IL-6) [R, R].
Therefore, this gene plays a very extensive role in triggering inflammation throughout your entire body.
SNPs in this gene, such as rs348373, have been associated with cognitive function — likely because it influences how vulnerable your brain is to chronic inflammation, which can have a significant impact on your overall cognitive ability [R, R, R].
To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on TNFSF9!
>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.
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