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TNFSF4
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs4916313 | |||
| rs16845585 | |||
| rs10465507 | |||
| rs10489268 | |||
| rs10798264 | |||
| rs10912558 | |||
| rs10912560 | |||
| rs10912561 | |||
| rs11808060 | |||
| rs13343107 | |||
| rs13343108 | |||
| rs17300347 | |||
| rs17346501 | |||
| rs17372309 | |||
| rs4113832 | |||
| rs4916314 | |||
| rs61826345 | |||
| rs61828261 | |||
| rs10912564 | |||
| rs11811856 |
Find on This Page
Summary
TNFSF4 encoes TNF superfamily member 4. Variants of TNFSF4 may play a role in lupus by increasing TNF-alpha signalling. It mediates adhesion of activated T cells to endothelial cells. Mutations of this gene are associated with lupus (R).
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing TNF-alpha.
Protein names
Found in These Blog Articles
GHR Function
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
More Information
The TNFSF4 gene encodes TNF superfamily member 4, an inflammatory signal that is part of the TNF signalling system. Once certain types of T cells are activated by TNF-alpha, TNFSF4 helps these cells move around the body to produce an immune response [R].
TNF-alpha, a type of cell signaling protein, is produced by different immune cells, including [R]:
- Macrophages
- Natural killer (NK) cells
- Neutrophils
- Mast cells
Besides inducing inflammation and fever, TNF-alpha can suppress appetite and stimulate phagocytosis (the process by which some white blood cells “swallow” and destroy damaged cells and pathogens) [R].
Variations in the TNFSF4 gene may cause improper TNF signalling and contribute to a range of health conditions, such as autoimmune diseases [R, R, R].
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