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SLC14A2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs181127124 | |||
| rs1377447834 | |||
| rs3745009 | |||
| rs2156609 | |||
| rs139829385 | |||
| rs145955125 | |||
| rs1484873 | |||
| rs149039485 | |||
| rs149251757 | |||
| rs199859786 | |||
| rs34461862 | |||
| rs371824385 | |||
| rs375269630 | |||
| rs750301658 | |||
| rs753899898 | |||
| rs760635115 | |||
| rs765167173 | |||
| rs1123617 | |||
| rs113938461 | |||
| rs1250518641 |
Find on This Page
Summary
SLC14A2 encodes urea transporter 2 (UT2). It plays a role in urinary transport. Variants of SLC14A2 may play a role in male-pattern baldness by altering urea metabolism. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by correcting urea metabolism and decreasing inflammation [R].
Protein names
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The SLC14A2 gene encodes solute carrier family 14 member 2, also called urea transporter 2 (UT2). This protein transports urea, the major waste product found in urine, within the filtration system of the kidneys [R, R].
As one might expect based on its function, UT2 is present mainly in the kidneys and bladder. It has been implicated in bladder cancer and other diseases of the urinary system [R, R].
Oddly, it has also been associated with male-pattern baldness. Hair loss has previously been linked to a type of kidney dysfunction, but this connection is rare [R, R, R, R].
High levels of uric acid in the blood may, in rare cases, promote the development of an autoimmune reaction that causes hair loss. It is unknown whether variants of SLC14A2 might encourage a similar reaction, or whether there is another mechanism for its association with hair loss [R].
Other research has found significant associations between urea metabolism and inflammation, and between inflammation and hair loss. It is possible that the link between SLC14A2 and male-pattern baldness is inflammatory in nature [R, R, R].
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