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REL
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs12989427 | |||
| rs13026050 | |||
| rs13031237 | |||
| rs1253930248 | |||
| rs13034020 | |||
| rs140063361 | |||
| rs140572082 | |||
| rs146672254 | |||
| rs149627368 | |||
| rs149938178 | |||
| rs188572845 | |||
| rs200515155 | |||
| rs34661029 | |||
| rs35043490 | |||
| rs35083477 | |||
| rs35245715 | |||
| rs6704900 | |||
| rs752105640 | |||
| rs757584747 | |||
| rs7590126 |
Find on This Page
Summary
REL encodes c-Rel, a protein that may promote the development of antibodies targeted to joints of the body. Variants of REL may play a role in rheumatoid arthritis by increasing the production or activity of c-Rel. It may also be linked to Hodgkin's lymphoma and ulcerative colitis [R].
Lifestyle and supplement modifications may counteract the effects of these variants by decreasing c-Rel production or activity.
Protein names
Found in These Blog Articles
More Information
The REL gene codes for c-Rel, a member of the NF-kB family. c-Rel combines with another member of its family in order to make a functional NF-kB protein [R].
NF-kB stimulates the production of inflammatory proteins, as well as promotes the formation of antibodies that recognize the body’s own tissues (autoantibodies). In this manner, NF-kB may play a major role in the development of autoimmune disorders, such as rheumatoid arthritis [R, R, R, R].
Variants of REL have been associated with rheumatoid arthritis. These variants may increase production or activity of c-Rel, leading to NF-kB-mediated production of inflammatory proteins and the formation of autoantibodies [R, R, R, R, R].
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