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REL (REL proto-oncogene, NF-kB subunit)

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Summary of REL

The gene codes for a protein, REL proto-oncogene, NF-kB subunit. Mutation or amplification is linked to B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms are linked to a susceptibility to ulcerative colitis and rheumatoid arthritis [R].

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The Function of REL

Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

Protein names

Recommended name:

Proto-oncogene c-Rel

REL SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13017599 (REL) ??
  2. RS13031237 (REL) ??
  3. RS34695944 (REL) ??
  4. RS842647 (REL) ??

Top Gene-Substance Interactions

REL Interacts with These Diseases

Disease Score

Substances That Increase REL

Substances Interaction Organism Category

Substances That Decrease REL

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: rheumatoid arthritis

     From NCBI Gene: This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014] From UniProt: Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • C/EBPbeta
  • IRF-1
  • c-Rel
  • NF-kappaB2

Gene Pathways:

  • Immune System

Molecular Function:

  • Chromatin Binding
  • Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • I-Kappab Kinase/Nf-Kappab Signaling
  • Inflammatory Response
  • Innate Immune Response
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Interferon-Beta Production
  • Negative Regulation Of Neuron Death
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Nik/Nf-Kappab Signaling
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Cytokine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| IMP| p68| NFkappaB| NF-kappaB| v-rel avian reticuloendotheliosis viral oncogene homolog| A306_06431| Anapl_09010| AS27_11303| AS28_01693| BmRelish| Bmrelish1| BmRelish2| CG11992 gene product from transcript CG11992-RA| CG11992-PA| CG11992-PB| CG11992-PC| CG11992-PD| c-Rel| C-Rel protein| c-rel proto-oncogene| C-Rel proto-oncogene protein| D623_10034307| Dmel_CG11992| H920_17534| I79_019798| immune response deficient 4| ird| ird4| M91_15511| M959_01204| N300_06343| N301_10971| N302_14380| N303_01192| N305_05031| N306_12961| N307_05847| N308_11893| N309_14886| N320_00925| N322_12432| N325_02383| N326_01411| N330_10431| N332_07014| N334_01489| N336_00365| N339_04859| N340_02169| NF-kappa-B transcription factor| nuclear factor NF-kappa-B p110 subunit| oncogene REL, avian reticuloendotheliosis| p68-c-rel| PAL_GLEAN10021230| PANDA_016962| positive regulation of transcription from RNA polymerase II promoter; GO:0045944| Proto-oncogene c-Rel| rel2| rel3| RelA| RELI| relish| relish1| relish2| relish homolog| Rel/NF-kappaB| Rel-p110| Rel-PA| Rel-PB| Rel-PC| Rel-PD| reticuloendotheliosis oncogene| TREES_T100000687| UY3_00837| v-rel| v-rel avian reticuloendotheliosis viral oncogene-like protein| v-rel reticuloendotheliosis viral oncogene homolog| v-rel reticuloendotheliosis viral oncogene-like protein| v-rel reticuloendotheliosis viral oncoprotein-like protein| xrel| Xrel2| Xrel3| Y1Q_006400| Y956_14518| Z169_07335| rel

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