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PTTG1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs76271047 | |||
| rs774743809 | |||
| rs7735342 | |||
| rs1075059 | |||
| rs1128026 | |||
| rs1192844817 | |||
| rs2910177 | |||
| rs138221856 | |||
| rs2910200 | |||
| rs2910202 | |||
| rs755760152 | |||
| rs79257708 | |||
| rs10056839 | |||
| rs1027968189 | |||
| rs4276447 | |||
| rs6556492 | |||
| rs199902471 | |||
| rs200605286 | |||
| rs55719355 | |||
| rs6889912 |
Find on This Page
Summary
PTTG1 encodes a protein called securin. Variants of PTTG1 may play a role in lupus by increasing TNF-alpha and c-myc.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing or blocking TNF-alpha and c-myc.
Protein names
Found in These Blog Articles
More Information
The PTTG1 gene encodes a protein called securin, which helps regulate cell division [R, R].
Like many other proteins involved in the cell cycle, securin has been implicated in the development of some kinds of cancer. According to one study, securin increases c-myc and TNF-alpha [R].
C-myc is an extremely important transcriptional regulator which is believed to have an effect on the expression of 15% of all other genes [R, R].
C-myc is heavily involved in the activation of T cells and innate lymphoid cells, two types of white blood cells. Innate lymphoid cells are part of the earliest immune response to many triggers [R, R, R].
TNF-alpha is an inflammatory signalling molecule produced by many types of white blood cells [R].
Besides inducing inflammation and fever, TNF-alpha can suppress appetite and stimulate phagocytosis (the process by which some white blood cells “swallow” and destroy damaged cells and pathogens) [R].
At least two variants of PTTG1 have been associated with lupus. Variants that increase securin production likely also increase c-myc and TNF-alpha, leading to increased susceptibility to autoimmune inflammation [R, R, R].
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