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Naps
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MTAP
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs7023954 | |||
| rs200018710 | |||
| rs10965146 | |||
| rs10114559 | |||
| rs10121449 | |||
| rs10757257 | |||
| rs10811623 | |||
| rs10811625 | |||
| rs10811626 | |||
| rs10965141 | |||
| rs10965143 | |||
| rs10965144 | |||
| rs10965145 | |||
| rs10965148 | |||
| rs113126107 | |||
| rs13297760 | |||
| rs199757658 | |||
| rs3922992 | |||
| rs4615669 | |||
| rs56726889 |
Find on This Page
Summary
The gene codes for an enzyme, methylthioadenosine phosphorylase. Variants of MTAP may play a role in melanoma by disrupting polyamine metabolism and decreasing interferon activity. It is not found very often in many cancers because this gene and the tumor suppressor p16 gene are co-deleted [R].
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by avoiding conditions that may be worse for those with low MTAP activity.
Protein names
Found in These Blog Articles
GHR Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
More Information
The MTAP gene encodes an enzyme called methylthioadenosine phosphorylase. This enzyme metabolizes molecules called polyamines, which are essential for cell growth and reproduction. Polyamine levels drop as people age, and low levels are also associated with stress and disease [R, R].
However, polyamine levels tend to be unusually high in cancer cells, possibly due to mutations in these cells. Some researchers have proposed targeting polyamines in future cancer treatments [R].
The MTAP gene is physically close to P16, a gene that prevents the development of tumors. P16 is often deleted in mutations that cause cancer, and MTAP is close enough that it tends to be deleted at the same time. As such, the MTAP enzyme is deficient in many types of cancer, including prostate cancer, osteosarcoma, and soft tissue sarcoma [R, R, R, R].
At least one variant in the MTAP gene has been associated with melanoma; researchers believe that risk alleles in MTAP lead to reduced expression of this gene and reduced activity of the MTAP enzyme [R, R, R].
MTAP is believed to affect the activity of STAT1, which is important in the context of cancer because STAT1 activates interferons alpha and beta (IFN-a and IFN-b). These immune system proteins may be deficient in melanoma, and some researchers have even suggested directly administering interferons in melanoma patients [R, R].
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