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MAP3K1
SNP Table
Find on This Page
Summary
The gene codes for a protein, mitogen-activated protein kinase kinase kinase 1. Autophosphorylation activates the protein. The protein requires magnesium as a cofactor in phosphorylating other proteins. [R].
Protein names
Found in These Blog Articles
GHR Function
The MAP3K1 gene provides instructions for making a protein that helps regulate signaling pathways that control various processes in the body, including the processes of determining sexual characteristics before birth. The MAP3K1 protein attaches (binds) to other molecules called RHOA, MAP3K4, FRAT1, and AXIN1. The binding of MAP3K1 to these molecules, which are called cofactors, helps MAP3K1 control the activity of the signaling pathways.
More Information
breast cancer Genetics Home Reference provides information about breast cancer. Langerhans cell histiocytosis Genetics Home Reference provides information about Langerhans cell histiocytosis. Swyer syndrome Mutations in the MAP3K1 gene are thought to account for up to 18 percent of cases of Swyer syndrome, a condition affecting sexual development also known as 46,XY complete gonadal dysgenesis or 46,XY pure gonadal dysgenesis. People usually have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Girls and women typically have two X chromosomes (46,XX karyotype), while boys and men usually have one X chromosome and one Y chromosome (46,XY karyotype). The MAP3K1 gene mutations that cause Swyer syndrome increase cofactor binding, which decreases signaling that leads to male sexual differentiation and enhances signaling that leads to female sexual differentiation. As a result, affected individuals with a typically male 46,XY karyotype will not develop male gonads (testes) but will develop female reproductive structures (a uterus and fallopian tubes). other disorders MAP3K1 gene mutations have also been identified in people with 46,XY disorder of sex development, which is also known as partial gonadal dysgenesis. These mutations likely have similar but less pronounced effects on signaling related to sexual development than those that cause Swyer syndrome (described above). Affected individuals may have external genitalia that do not look clearly male or clearly female (ambiguous genitalia) or other abnormalities of the genitals and reproductive organs.
The MAP3K1 gene provides instructions for making a protein that helps regulate signaling pathways that control various processes in the body, including the processes of determining sexual characteristics before birth. The MAP3K1 protein attaches (binds) to other molecules called RHOA, MAP3K4, FRAT1, and AXIN1. The binding of MAP3K1 to these molecules, which are called cofactors, helps MAP3K1 control the activity of the signaling pathways.
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