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IRGM
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs147731042 | |||
| rs10065172 | |||
| rs2880791 | |||
| rs2344180 | |||
| rs1820682 | |||
| rs10051412 | |||
| rs10051804 | |||
| rs10051924 | |||
| rs10052080 | |||
| rs10058821 | |||
| rs10058943 | |||
| rs10077333 | |||
| rs10078968 | |||
| rs10875560 | |||
| rs11167514 | |||
| rs111719118 | |||
| rs112017023 | |||
| rs112483869 | |||
| rs113195856 | |||
| rs113199847 |
Find on This Page
Summary
Protein names
Found in These Blog Articles
GHR Function
The IRGM gene provides instructions for making a protein that plays an important role in the immune system. This protein is involved in a process called autophagy, which cells use to surround and destroy foreign invaders such as bacteria and viruses. Specifically, the IRGM protein helps trigger autophagy in cells infected with certain kinds of bacteria (mycobacteria), including the type of bacteria that causes tuberculosis. In addition to protecting cells from infection, autophagy is used to recycle worn-out cell parts and break down certain proteins when they are no longer needed. This process also plays an important role in controlled cell death (apoptosis).
More Information
IRGM (Immunity-related GTPase M) encodes a protein that plays a role in the immune system response. It regulates autophagy formation in response to pathogens (R).
Polymorphisms are associated with a higher risk for Crohn's disease and tuberculosis (R).
Crohn disease Several variations in or near the IRGM gene have been associated with an increased risk of developing Crohn disease. This increased risk has been found primarily in white populations. IRGM variations change single DNA building blocks (nucleotides) in regions of DNA that may regulate when and how the IRGM protein is produced. It is unclear how these changes influence a person’s chance of developing Crohn disease. Researchers suspect that changes involving the IRGM protein may disrupt the autophagy process, preventing the immune system from destroying harmful bacteria effectively. An abnormal immune response to bacteria in the intestinal walls may lead to chronic inflammation and the digestive problems characteristic of Crohn disease.
The IRGM gene provides instructions for making a protein that plays an important role in the immune system. This protein is involved in a process called autophagy, which cells use to surround and destroy foreign invaders such as bacteria and viruses. Specifically, the IRGM protein helps trigger autophagy in cells infected with certain kinds of bacteria (mycobacteria), including the type of bacteria that causes tuberculosis. In addition to protecting cells from infection, autophagy is used to recycle worn-out cell parts and break down certain proteins when they are no longer needed. This process also plays an important role in controlled cell death (apoptosis).
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