IL23R

SNP Table

variant	genotype	frequency	risk allele
rs1884444
rs4655688
rs11209026
rs953679482
rs7530511
rs10889665
rs10889667
rs10889668
rs11801083
rs1358748
rs1358749
rs4655689
rs4655690
rs6588247
rs6687620
rs10127763
rs10489630
rs7534570
rs12069782
rs12090164

22541 associated SNPs in total

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Summary Blog Articles GHR Function Frequently Asked Questions

Summary

IL23R (interleukin 23 receptor) encodes for a protein this is required for IL23A signaling (R).

Polymorphisms of this gene are associated with higher risk for:

asthma (R)
high cholesterol (R)
tuberculosis (R)

Studies in animal models of multiple sclerosis showed that IL-23 was responsible for the inflammation observed, not IL-12 as previously thought. Subsequently, IL-23 was shown to facilitate development of inflammation in numerous other models of immune disease where IL-12 had previously been implicated including models of arthritis, intestinal inflammation, and psoriasis.

Protein names

interleukin 23 receptor [Source:HGNC Symbol;Acc:HGNC:19100]

Found in These Blog Articles

The Gene Involved in Gut Inflammation and IBD (IL23R)

IL23R encodes a receptor for IL-23, a pro-inflammatory cytokine. Click to learn how variants in this gene correlate with IBD.

GHR Function

The IL23R gene provides instructions for making a protein called the interleukin 23 receptor. This protein is embedded in the cell membrane of several types of immune system cells, including T cells, natural killer (NK) cells, monocytes, and dendritic cells. These cells identify foreign substances and defend the body against infection and disease.

At the cell surface, the interleukin 23 receptor interacts with a protein called interleukin 23. These two proteins fit together like a lock and its key. Interleukin 23 is a cytokine, which is a type of protein that regulates the activity of immune system cells. When interleukin 23 binds to its receptor, it triggers a series of chemical signals inside the cell. These signals promote inflammation and help coordinate the immune system’s response to foreign invaders such as bacteria and viruses.

More Information

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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