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GAS8
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs2302513 | |||
| rs141063112 | |||
| rs3743825 | |||
| rs868045 | |||
| rs17178299 | |||
| rs3833069 | |||
| rs142296775 | |||
| rs1048148 | |||
| rs3743827 | |||
| rs3743828 | |||
| rs4785767 | |||
| rs180740547 | |||
| rs112601651 | |||
| rs114684931 | |||
| rs11648422 | |||
| rs116654360 | |||
| rs3743821 | |||
| rs3743826 | |||
| rs4374173 | |||
| rs4464078 |
Find on This Page
Summary
CASP8 encodes caspase-8, a protein that may promote the death of both cancerous cells and protective immune cells. A variant of CASP8 may play a role in melanoma by dysregulating caspase-8 production. Lifestyle and diet modifications may counteract the effects of this variant by balancing or limiting the production of caspase-8.
Protein names
Found in These Blog Articles
More Information
The CASP8 gene codes for caspase-8, a player in one of the programmed cell death (apoptosis) pathways of cells [R].
Apoptosis is a regulated process that results in cell shrinkage and breakdown. This process is essential for the immune cell-mediated removal of infected, damaged, or cancerous cells. In cancer, cells are often able to evade apoptosis and continue dividing uncontrollably [R, R].
While this may imply that caspase-8 levels are low in cancer patients, studies have suggested that low apoptotic activity may actually be beneficial in immune cells that function to clear cancerous cells [R].
In addition, caspase-8 has been shown to increase the activity of the protein NF-kB, which may promote tumor development by elevating levels of pro-inflammatory immune proteins (cytokines) [R].
Ultimately, caspase-8 levels are likely required to remain balanced in order to avoid unwanted effects.
A variant of CASP8 has been associated with melanoma, a form of skin cancer. This variant may alter the production of caspase-8, leading to dysregulated apoptosis in melanoma cells and immune cells [R, R, R].
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