• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CASP8

CASP8 (Caspase 8)

Loading...

The Function of CASP8

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Caspase-8

Short name:

CAP4

Alternative name(s):

CASP-8
Apoptotic cysteine protease
Apoptotic protease Mch-5
FADD-homologous ICE/ced-3-like protease
FADD-like ICE
FLICE
ICE-like apoptotic protease 5
MORT1-associated ced-3 homolog
MACH

CASP8 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1045485 (CASP8) ??
  2. RS13016963 (CASP8) ??
  3. RS3769825 (CASP8) ??
  4. RS3769827 (CASP8) ??
  5. RS3834129 (CASP8) ??

Top Gene-Substance Interactions

CASP8 Interacts with These Diseases

Disease Score

Substances That Increase CASP8

Substances Interaction Organism Category

Substances That Decrease CASP8

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: autoimmune lymphoproliferative syndromebreast cancerFrom NCBI Gene: Caspase-8 deficiencyHepatocellular carcinomaFamilial cancer of breastLung cancerFrom UniProt: Caspase-8 deficiency (CASP8D): Disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization. [MIM:607271]

     From NCBI Gene: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] From UniProt: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • STAT3
  • Sp1
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • FOXO1a
  • FOXO1
  • IRF-2

Tissue specificity:

Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.

Gene Pathways:

  • Immune System
  • Apoptosis
  • Chagas disease (American trypanosomiasis)
  • Tuberculosis
  • Toxoplasmosis
  • Pathways in cancer
  • Toll-like receptor signaling pathway
  • Huntington's disease
  • Alzheimer's disease
  • Viral myocarditis
  • NOD-like receptor signaling pathway
  • Apoptosis
  • p53 signaling pathway
  • Innate Immune System
  • RIG-I-like receptor signaling pathway

Enzyme Regulation:

Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis.

Molecular Function:

  • Cysteine-Type Endopeptidase Activity
  • Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
  • Cysteine-Type Peptidase Activity
  • Death Effector Domain Binding
  • Peptidase Activity
  • Scaffold Protein Binding
  • Ubiquitin Protein Ligase Binding
  • Identical Protein Binding

Biological Processes:

  • Activation Of Cysteine-Type Endopeptidase Activity
  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
  • Apoptotic Process
  • Apoptotic Signaling Pathway
  • B Cell Activation
  • Cell Surface Receptor Signaling Pathway
  • Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
  • Cellular Response To Mechanical Stimulus
  • Cellular Response To Organic Cyclic Compound
  • Death-Inducing Signaling Complex Assembly
  • Execution Phase Of Apoptosis
  • Extrinsic Apoptotic Signaling Pathway
  • Macrophage Differentiation
  • Natural Killer Cell Activation
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Negative Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Nucleotide-Binding Oligomerization Domain Containing Signaling Pathway
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Macrophage Differentiation
  • Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
  • Positive Regulation Of Proteolysis
  • Protein Heterooligomerization
  • Proteolysis
  • Proteolysis Involved In Cellular Protein Catabolic Process
  • Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
  • Regulation Of Necrotic Cell Death
  • Regulation Of Tumor Necrosis Factor-Mediated Signaling Pathway
  • Response To Antibiotic
  • Response To Cobalt Ion
  • Response To Cold
  • Response To Estradiol
  • Response To Ethanol
  • Response To Lipopolysaccharide
  • Response To Tumor Necrosis Factor
  • Suppression By Virus Of Host Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
  • Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
  • T Cell Activation
  • Trail-Activated Apoptotic Signaling Pathway
  • Trif-Dependent Toll-Like Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ALPS2B| Anapl_12750| apoptotic cysteine protease| apoptotic protease Mch-5| AS28_03248| CAP4| Casp-8| CASP8-s| Caspase-8| caspase-8a| caspase 8, apoptosis-related cysteine peptidase| caspase 8, apoptosis-related cysteine protease| caspase-8-like cysteine peptidase| CB1_001286010| cysteine protease| DEATH effector domain caspase| DED caspase| FADD-homologous ICE/CED-3-like protease| FADD-like ICE| Fas-linked ICE-like protease| FLICE| H920_02343| ICE-like apoptotic protease 5| MACH| MACH-alpha-1/2/3 protein| MACH-beta-1/2/3/4 protein| MCH5| MDA_GLEAN10008508| MORT1-associated ced-3 homolog| N301_02460| N302_09791| N306_11814| N310_05621| N311_03453| N322_04773| N328_04229| N330_10359| N335_13640| N336_10212| N341_03664| PAL_GLEAN10026114| PANDA_003926| TREES_T100003111| xcaspase 8| xCaspase-8| Y1Q_015954| Y956_07524| Z169_07017| casp8

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved