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CSK
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs3784789 | |||
| rs184405931 | |||
| rs4886410 | |||
| rs2168519 | |||
| rs6495127 | |||
| rs7497201 | |||
| rs8031121 | |||
| rs8032336 | |||
| rs11635664 | |||
| rs12442901 | |||
| rs12898997 | |||
| rs1350193 | |||
| rs1378940 | |||
| rs1378941 | |||
| rs1378942 | |||
| rs2168518 | |||
| rs2301249 | |||
| rs34933034 | |||
| rs35213055 | |||
| rs3784790 |
Find on This Page
Summary
This gene encodes a protein called C-crc tyrosine kinase [R].
This protein has multiple functions [R, R]:
- Helping cells grow and specialize during development
- Activating T and B cells, which attack pathogens and prevent disease
- Regulating blood pressure
Likely because of its role in the immune response, some variants in the CSK gene have been linked to autoimmune disease [R].
CSK also helps make a protein that suppresses angiotensin II production. Angiotensin II is the key component of the renin-angiotensin system (RAS). It raises blood pressure by shrinking the blood vessels, increasing blood volume, and activating the sympathetic nervous system [R, R, R].
Protein names
Found in These Blog Articles
More Information
The CSK gene helps make a protein that suppresses angiotensin II production. Angiotensin II is the key component of the renin-angiotensin system (RAS). It raises blood pressure by shrinking the blood vessels, increasing blood volume, and activating the sympathetic nervous system [R, R, R].
Popular blood pressure drugs, ACE inhibitors, target the RAS system by inhibiting the enzyme that produces angiotensin II [R].
Did you know? The CSK gene belongs to a group of 21 genes associated with blood pressure. Using cutting-edge genetic methods, scientists concluded that, of all those genes, CSK is most likely the one directly influencing blood pressure [R]!
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