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CREBL2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs11613846 | |||
| rs12580006 | |||
| rs4763859 | |||
| rs10845599 | |||
| rs12830917 | |||
| rs4555 | |||
| rs34975957 | |||
| rs117238070 | |||
| rs11609280 | |||
| rs2900297 | |||
| rs34051318 | |||
| rs35229871 | |||
| rs541403688 | |||
| rs61915606 | |||
| rs7131825 | |||
| rs10772585 | |||
| rs10772586 | |||
| rs10845596 | |||
| rs10845597 | |||
| rs12822507 |
Find on This Page
Summary
CREBL2 codes for a protein that interacts with the gene regulator CREB in order to promote its activity. CREB may be involved in preventing autoimmunity and inflammation. Variants of CREBL2 may play a role in lupus by decreasing CREBL2 production, thereby lowering the activity of CREB..It can also act as a tumor suppressor (R).
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing CREB activity.
Protein names
Found in These Blog Articles
More Information
The CREBL2 gene codes for cAMP responsive element-binding protein-like 2 (CREBL2), a protein that may interact with the gene regulator CREB in order to promote its activity [R, R].
CREB may help stimulate the production of interleukin-2 (IL-2), an immune system messenger (cytokine) that promotes the development of regulatory T cells (Tregs). Tregs are involved in suppressing the formation of autoantibodies, or antibodies that recognize the body’s own tissues. In this manner, Tregs may function to prevent lupus and other autoimmune disorders [R, R, R].
IL-2 also helps prevent the production of T helper 17 (Th17) immune system cells. Th17 cells release inflammatory cytokines that may be involved in the progression of organ damage in lupus, such as TNF-alpha [R, R, R].
Variants of CREBL2 have been associated with lupus. These variants may decrease the production of CREBL2, leading to reduced activity of CREB, decreased production of IL-2, autoantibody formation, and inflammation [R, R, R].
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