inflammation & autoimmunity

CREBL2

The Role of a Gene Regulator in Lupus (CREBL2)

Written by Shany Lahan, MS (Neuroscience) on December 8th, 2020

The CREBL2 gene is involved in the prevention of inflammation and autoimmunity. Read more to find out how variants of CREBL2 may promote the development of the autoimmune disorder lupus.

Summary

CREBL2 codes for a protein that interacts with the gene regulator CREB in order to promote its activity. CREB may be involved in preventing autoimmunity and inflammation. Variants of CREBL2 may play a role in lupus by decreasing CREBL2 production, thereby lowering the activity of CREB. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by increasing CREB activity.

CREBL2 and Lupus

The CREBL2 gene codes for cAMP responsive element-binding protein-like 2 (CREBL2), a protein that may interact with the gene regulator CREB in order to promote its activity [R, R].

CREB may help stimulate the production of interleukin-2 (IL-2), an immune system messenger (cytokine) that promotes the development of regulatory T cells (Tregs). Tregs are involved in suppressing the formation of autoantibodies, or antibodies that recognize the body’s own tissues. In this manner, Tregs may function to prevent lupus and other autoimmune disorders [R, R, R].

IL-2 also helps prevent the production of T helper 17 (Th17) immune system cells. Th17 cells release inflammatory cytokines that may be involved in the progression of organ damage in lupus, such as TNF-alpha [R, R, R].

Variants of CREBL2 have been associated with lupus. These variants may decrease the production of CREBL2, leading to reduced activity of CREB, decreased production of IL-2, autoantibody formation, and inflammation [R, R, R].

Your CREBL2 Results for Lupus

SNP Table

variant	genotype	frequency	risk allele
rs10845606
rs12822507

Primary SNP:

CREBL2 rs10845606 [R, R]

‘C’ = Higher odds of lupus, relative to ‘A’
‘A’ = Lower odds of lupus, relative to ‘C’

Other Important SNPs:

CREBL2 rs12822507 [R]

‘A’ = Higher odds of lupus, relative to ‘G’
‘G’ = Lower odds of lupus, relative to ‘A’

Recommendations

Lifestyle

Acupuncture

Multiple studies have demonstrated that acupuncture may increase the activity of CREB [R, R, R].

Acupuncture may also help relieve muscle pain associated with lupus. In a small trial of lupus patients, standard care failed to reduce pain, while a 10-session course of acupuncture reduced pain by at least 30% in the 40% of patients who received it [R].

Acupuncture may help manage lupus by increasing the activity of CREB.

Diet

Green Tea

A number of compounds in green tea have been found to promote the activity of CREB, suggesting that green tea may be beneficial for individuals carrying risk variants of CREBL2 [R, R].

In a randomized controlled trial of people with lupus, 1000 mg per day of a green tea extract containing 22% polyphenols (equivalent to one cup of green tea) for 12 weeks improved disease severity and quality of life [R].

Green tea may help manage lupus by increasing the activity of CREB.

Supplements

DHEA

DHEA should never be used without the prescription or recommendation of a medical professional. Talk to your doctor before using DHEA for any purpose.

DHEA increased the activity of CREB in multiple cell- and animal-based studies. In one of these studies, the DHEA-mediated increase in CREB activity was linked to reduced inflammation [R, R, R].

Supplementation with DHEA reduced lupus severity, flares, bone loss from corticosteroids, the need for this medication, and an immune protein (IL-10), all while improving quality of life, in 10 clinical trials of people with active, mild-to-moderate lupus [R, R, R, R, R, R, R, R, R, R, R].

However, it didn’t help prevent clogged arteries or osteoporosis, worsened blood fat profile, and showed no benefits in people with severe or inactive lupus. A meta-analysis concluded that it may only have short-term benefits on quality of life [R, R, R, R, R].

DHEA may help manage lupus by increasing the activity of CREB.

Shany Lahan

MS (Neuroscience)

Shany received her MSc in Neuroscience from Western University.

Prior to joining SelfDecode, Shany conducted research related to Alzheimer’s disease, and taught science to undergraduate students. She believes that research should be accessible to everyone, regardless of scientific background. Shany joined SelfDecode with a mission to help others optimize their health and wellbeing – as well as help them understand the science behind it all.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

More inflammation & autoimmunity blogs

How to Combat Histamine Intolerance Through Genetics (DAO) Are You Genetically Vulnerable to High Brain Histamine, Migraines, or ADHD? (HNMT) How to Tell if You’re Lectin Sensitive Using Your Genetic Data (CNR1) Are You Sensitive to Lectins? (MTHFR) Fight Oxidative Stress, Inflammation, and Brain Fog (PARP1) Is This Gene Causing Your Autoimmune Problems? (PTPN22) Are You Genetically Susceptible to Post-Treatment Lyme? (ABCB1) A Key Genetic Player in Autoimmunity (HLA-B) Is This Inflammation Gene Reducing Your Intelligence? (TNFSF9) Can You Manage Allergies and Asthma by Balancing Methylation? (MTHFR)

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Summary CREBL2 and Lupus Your CREBL2 Results for Lupus

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