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CDK10
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs146732625 | |||
| rs201507040 | |||
| rs766960979 | |||
| rs115025067 | |||
| rs1443402777 | |||
| rs200970530 | |||
| rs13330285 | |||
| rs13335097 | |||
| rs116853582 | |||
| rs3840852 | |||
| rs164746 | |||
| rs11076612 | |||
| rs1255831706 | |||
| rs12924138 | |||
| rs12924572 | |||
| rs164742 | |||
| rs164744 | |||
| rs2075880 | |||
| rs62068364 | |||
| rs8404 |
Find on This Page
Summary
CDK10 encodes cyclin dependent kinase 10. Variants of CDK10 may play a role in melanoma by disrupting the cell cycle.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by stabilizing the cell cycle and preventing uncontrolled growth.
Protein names
Found in These Blog Articles
More Information
The CDK10 gene encodes a protein called cyclin dependent kinase 10. This protein plays a role in the growth and reproduction of cells at a very specific point during the cell’s reproductive cycle [R].
Mutations in CDK10 have been linked to STAR syndrome, a very rare condition that causes deformities in the fingers, toes, skull, anus, genitals, and kidneys; other organs and systems may also be affected. Variants associated with STAR syndrome appear to decrease the production of the CDK10 protein [R, R].
Oddly, variation in the CDK10 gene is also believed to affect hair and skin color as well as body weight [R, R].
Many cancers develop when cells lose the ability to regulate their own growth and reproduction. Because of CDK10’s role in the cell cycle, it has been extensively studied for its relationship to cancer in general and melanoma in particular [R].
CDK10 interacts with ETS2, another protein that has been strongly associated with melanoma. Through ETS2, variants in CDK10 may allow cells to reproduce without the usual control mechanisms of the cell cycle. Cells that reproduce uncontrollably form tumors, which can then become cancerous [R, R].
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