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CDK10

Disruptions of the Cell Cycle in Melanoma Development (CDK10)

Written by Jasmine Foster, BSc, BEd on January 7th, 2021

The CDK10 gene encodes a protein that helps regulate the growth and reproduction of cells. What is its role in melanoma? Read on to find out.

Summary

CDK10 encodes cyclin dependent kinase 10. Variants of CDK10 may play a role in melanoma by disrupting the cell cycle. Lifestyle, diet, and supplement modifications may counteract the effects of these variants by stabilizing the cell cycle and preventing uncontrolled growth.

CDK10 and Melanoma

The CDK10 gene encodes a protein called cyclin dependent kinase 10. This protein plays a role in the growth and reproduction of cells at a very specific point during the cell’s reproductive cycle [R].

Mutations in CDK10 have been linked to STAR syndrome, a very rare condition that causes deformities in the fingers, toes, skull, anus, genitals, and kidneys; other organs and systems may also be affected. Variants associated with STAR syndrome appear to decrease the production of the CDK10 protein [R, R].

Oddly, variation in the CDK10 gene is also believed to affect hair and skin color as well as body weight [R, R].

Many cancers develop when cells lose the ability to regulate their own growth and reproduction. Because of CDK10’s role in the cell cycle, it has been extensively studied for its relationship to cancer in general and melanoma in particular [R].

CDK10 interacts with ETS2, another protein that has been strongly associated with melanoma. Through ETS2, variants in CDK10 may allow cells to reproduce without the usual control mechanisms of the cell cycle. Cells that reproduce uncontrollably form tumors, which can then become cancerous [R, R].

The CDK10 gene encodes a protein that helps regulate the growth and reproduction of cells. Some variants of this gene may interact with ETS2 to promote unregulated cell growth and melanoma.

Your CDK10 Results for Melanoma

SNP Table

variant	genotype	frequency	risk allele
rs35063026
rs258322

CDK10 rs35063026 [R]

‘C’ = Associated with relatively lower rates of melanoma
‘T’ = Associated with relatively higher rates of melanoma
The ‘T’ allele may interact with ETS2 to promote unregulated cell growth and melanoma [R, R].

CDK10 rs258322 [R, R, R]

‘G’ = Associated with relatively lower rates of melanoma
‘A’ = Associated with relatively higher rates of melanoma
The ‘A’ allele may interact with ETS2 to promote unregulated cell growth and melanoma [R, R].

Recommendations

Avoid UV Exposure

Ultraviolet light exposure can cause disruptions to the regulation of the cell cycle by damaging DNA. This may be especially dangerous for people with detrimental CDK10 variants who may already have disrupted cell cycles [R].

Excessive, unprotected exposure to UV radiation is by far the main risk factor for the development of melanoma. UV from both the sun and artificial sources (tanning beds and sun lamps) damages the DNA of pigment-producing cells (melanocytes), potentially causing mutations that turn these cells into melanomas [R, R, R].

People with low levels of the protective pigment melanin, who typically have fair skin, blond or red hair, and light-colored eyes, are at higher risk of melanoma than those with dark skin [R].

Alternatively, every single mole has a small probability of turning into cancer. Having a high number of moles, especially if they are large or have atypical features, also increases the risk of this skin cancer type [R, R].

Reducing exposure to UV by limiting sun exposure (especially during the middle of the day), wearing protective clothing and sunscreen, and being aware of skin-sensitizing medications can greatly reduce the risk of melanoma.

Exposure to UV light can cause DNA damage and disrupt the cell cycle. UV radiation is also a major risk factor for melanoma.

B Vitamins

Vitamins B9 (folate) and B12 (cobalamin) help regulate the cell cycle, and deficiencies in these nutrients may cause disruptions to the normal growth and reproduction of cells. People with detrimental CDK10 variants, who may already be prone to disruptions in the cell cycle, should be sure to get enough B9 and B12 either through their diets or supplementation [R].

Supplementation with a combination of vitamin B6 (pyridoxine), folate, and B12 was associated with a reduced incidence of melanoma in 3 studies of over 119,000 people [R, R, R].

The National Institutes of Health recommends an intake of at least 400 mcg of folate and 2.4 mcg of vitamin B12 per day. Liver and green vegetables are the richest dietary sources of folate; shellfish, fish, and liver are the richest dietary sources of B12 [R, R].

Deficiencies in vitamins B9 and B12 may disrupt the cell cycle, and supplementing with these vitamins has been linked to a reduced incidence of melanoma.

Jasmine Foster

BSc, BEd

Jasmine received her BS from McGill University and her BEd from Vancouver Island University.

Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

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Summary CDK10 and Melanoma Your CDK10 Results for Melanoma

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Disruptions of the Cell Cycle in Melanoma Development (CDK10)

Summary

CDK10 and Melanoma

Your CDK10 Results for Melanoma

SNP Table

Recommendations

Avoid UV Exposure

B Vitamins

Disclaimer

More skin & beauty blogs

More cancer blogs

Content

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Ultimate Bundle

Limited Time Offer 25% Off

Policies

About

Navigation

Health reports