• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. CD28

CD28 (CD28 molecule)

Loading...

The Function of CD28

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

T-cell-specific surface glycoprotein CD28

Short name:

TP44

Alternative name(s):

CD antigen CD28

CD28 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1980422 (CD28) ??
  2. RS3116494 (CD28) ??
  3. RS3116496 (CD28) ??
  4. RS3181096 (CD28) ??
  5. RS3181098 (CD28) ??
  6. RS4675361 (CD28) ??

Top Gene-Substance Interactions

CD28 Interacts with These Diseases

Disease Score

Substances That Increase CD28

Substances Interaction Organism Category

Substances That Decrease CD28

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: rheumatoid arthritis

     From NCBI Gene: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] From UniProt: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • NF-AT2

Tissue specificity:

Expressed in T-cells and plasma cells, but not in less mature B-cells.

Gene Pathways:

  • Disease
  • Immune System
  • Signal Transduction
  • Autoimmune thyroid disease
  • Measles
  • T cell receptor signaling pathway
  • Cell adhesion molecules (CAMs)
  • Allograft rejection
  • Graft-versus-host disease
  • Intestinal immune network for IgA production
  • Rheumatoid arthritis
  • Type I diabetes mellitus
  • Systemic lupus erythematosus
  • Viral myocarditis

Molecular Function:

  • Coreceptor Activity
  • Identical Protein Binding
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
  • Protease Binding
  • Sh3/Sh2 Adaptor Activity

Biological Processes:

  • Apoptotic Signaling Pathway
  • Cell Surface Receptor Signaling Pathway
  • Cytokine Biosynthetic Process
  • Humoral Immune Response
  • Negative Regulation Of Gene Expression
  • Negative Thymic T Cell Selection
  • Phosphatidylinositol-Mediated Signaling
  • Positive Regulation Of Alpha-Beta T Cell Proliferation
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Inflammatory Response To Antigenic Stimulus
  • Positive Regulation Of Interleukin-10 Production
  • Positive Regulation Of Interleukin-2 Biosynthetic Process
  • Positive Regulation Of Interleukin-4 Production
  • Positive Regulation Of Isotype Switching To Igg Isotypes
  • Positive Regulation Of Mitotic Nuclear Division
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Translation
  • Positive Regulation Of Viral Genome Replication
  • Regulation Of Defense Response To Virus By Virus
  • Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Regulation Of Regulatory T Cell Differentiation
  • Regulatory T Cell Differentiation
  • T Cell Costimulation
  • T Cell Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| antigen CD28| AS27_10574| AS28_03287| CB1_002756019| CD28 antigen| CD28 antigen (Tp44)| CD28 precursor 6m| CD28 precursor P| CD28 precursor protein| CD28RNA| cell surface protein| CHT28| costimulatory molecule B7 receptor CD28| costimulatory receptor CD28| D623_10028408| EGK_04709| GW7_21653| H920_20286| I79_003017| Inducible T-cell costimulator| M91_06412| M959_07256| MDA_GLEAN10017302| MFASCD28-6m| MFASCD28-P| N300_08693| N301_02505| N302_06686| N303_08463| N305_06694| N307_04176| N308_00973| N309_05340| N310_05960| N311_01196| N312_04058| N320_11659| N321_01543| N322_02587| N324_10244| N325_04885| N326_12158| N327_02684| N328_01555| N329_05467| N330_04528| N331_00990| N332_04774| N333_04165| N334_02815| N335_09974| N336_05534| N339_09908| N340_07237| N341_03016| PAL_GLEAN10026139| PANDA_008675| T-cell costimulatory molecule CD28| T-cell-specific surface glycoprotein CD28| t-cell-specific surface glycoprotein CD28 homolog| Tp44| TREES_T100003129| uncharacterized protein LOC103389879| Y1Q_012450| Y956_07565| Z169_11472| cd28

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved