The Function of CD28
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
Protein names
Recommended name:
T-cell-specific surface glycoprotein CD28Short name:
TP44Alternative name(s):
CD antigen CD28- RS1980422 (CD28) ??
- RS3116494 (CD28) ??
- RS3116496 (CD28) ??
- RS3181096 (CD28) ??
- RS3181098 (CD28) ??
- RS4675361 (CD28) ??
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Top Gene-Substance Interactions
CD28 Interacts with These Diseases
| Disease | Score |
Substances That Increase CD28
| Substances | Interaction | Organism | Category |
Substances That Decrease CD28
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: rheumatoid arthritis
From NCBI Gene: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] From UniProt: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in T-cells and plasma cells, but not in less mature B-cells.
Gene Pathways:
- Disease
- Immune System
- Signal Transduction
- Autoimmune thyroid disease
- Measles
- T cell receptor signaling pathway
- Cell adhesion molecules (CAMs)
- Allograft rejection
- Graft-versus-host disease
- Intestinal immune network for IgA production
- Rheumatoid arthritis
- Type I diabetes mellitus
- Systemic lupus erythematosus
- Viral myocarditis
Molecular Function:
- Coreceptor Activity
- Identical Protein Binding
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity
- Protease Binding
- Sh3/Sh2 Adaptor Activity
Biological Processes:
- Apoptotic Signaling Pathway
- Cell Surface Receptor Signaling Pathway
- Cytokine Biosynthetic Process
- Humoral Immune Response
- Negative Regulation Of Gene Expression
- Negative Thymic T Cell Selection
- Phosphatidylinositol-Mediated Signaling
- Positive Regulation Of Alpha-Beta T Cell Proliferation
- Positive Regulation Of Gene Expression
- Positive Regulation Of Inflammatory Response To Antigenic Stimulus
- Positive Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-2 Biosynthetic Process
- Positive Regulation Of Interleukin-4 Production
- Positive Regulation Of Isotype Switching To Igg Isotypes
- Positive Regulation Of Mitotic Nuclear Division
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Protein Kinase B Signaling
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Translation
- Positive Regulation Of Viral Genome Replication
- Regulation Of Defense Response To Virus By Virus
- Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Regulation Of Regulatory T Cell Differentiation
- Regulatory T Cell Differentiation
- T Cell Costimulation
- T Cell Receptor Signaling Pathway