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CCL21
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs777471870 | |||
| rs148496138 | |||
| rs142807238 | |||
| rs375910980 | |||
| rs755668682 | |||
| rs11574915 | |||
| rs10972211 | |||
| rs11574916 | |||
| rs1323829310 | |||
| rs1377466469 | |||
| rs1396951130 | |||
| rs147542625 | |||
| rs149966060 | |||
| rs1801937 | |||
| rs199843101 | |||
| rs200916713 | |||
| rs201649217 | |||
| rs370077092 | |||
| rs371151997 | |||
| rs373192306 |
Find on This Page
Summary
The CCL21 gene helps make a protein that contributes to joint inflammation. Certain gene variants may increase CCL21 activity and correlate with higher odds of rheumatoid arthritis.
Protein names
Found in These Blog Articles
More Information
The CCL21 gene codes for a protein that can stimulate inflammation and the growth of blood vessels in rheumatoid arthritis-affected tissue. More precisely, CCL21 binds CCR7 and triggers the production of different inflammatory proteins and growth factors (such as IL-6, IL-23, and VEGF) [R, R, R].
This cascade of inflammation and blood vessel growth results in joint pain, swelling, and stiffness—the hallmarks of rheumatoid arthritis. People with rheumatoid arthritis have significantly higher CCL21 levels in their joints [R, R, R].
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