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CASP8
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs3769823 | |||
| rs3769824 | |||
| rs6723097 | |||
| rs3769827 | |||
| rs10178982 | |||
| rs10206231 | |||
| rs11687854 | |||
| rs11691602 | |||
| rs6761514 | |||
| rs72937111 | |||
| rs1476137451 | |||
| rs7578970 | |||
| rs375598463 | |||
| rs13023732 | |||
| rs10635401 | |||
| rs10804111 | |||
| rs10931936 | |||
| rs1861270 | |||
| rs2349070 | |||
| rs3185378 |
Find on This Page
Summary
CASP8 encodes caspase-8, a protein that may promote the death of both cancerous cells and protective immune cells. A variant of CASP8 may play a role in melanoma by dysregulating caspase-8 production. Lifestyle and diet modifications may counteract the effects of this variant by balancing or limiting the production of caspase-8.
Protein names
Found in These Blog Articles
More Information
The CASP8 gene codes for caspase-8, a player in one of the programmed cell death (apoptosis) pathways of cells [R].
Apoptosis is a regulated process that results in cell shrinkage and breakdown. This process is essential for the immune cell-mediated removal of infected, damaged, or cancerous cells. In cancer, cells are often able to evade apoptosis and continue dividing uncontrollably [R, R].
While this may imply that caspase-8 levels are low in cancer patients, studies have suggested that low apoptotic activity may actually be beneficial in immune cells that function to clear cancerous cells [R].
In addition, caspase-8 has been shown to increase the activity of the protein NF-kB, which may promote tumor development by elevating levels of pro-inflammatory immune proteins (cytokines) [R].
Ultimately, caspase-8 levels are likely required to remain balanced in order to avoid unwanted effects.
A variant of CASP8 has been associated with melanoma, a form of skin cancer. This variant may alter the production of caspase-8, leading to dysregulated apoptosis in melanoma cells and immune cells [R, R, R].
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