High Blood Sugar
Anxiety
Gluten Sensitivity
Gut Inflammation
Blood Pressure
IBS
Mood
Insomnia
PTSD
Mood Swings
Overweight
Memory Performance
Sexual Dysfunction
PCOS
Psoriasis
Joint Pain
Attention/ADHD
Chronic Fatigue / Tiredness
Allergies
Asthma
Acne
Tinnitus
Eczema
Food Allergy
Vitamin B6
Vitamin E
Restless Leg Syndrome
Grinding Teeth
Vitamin A
Magnesium
Zinc
Heart Health
Migraines
(High) Cholesterol
Headache
Chronic Pain
Back pain
Shoulder & Neck Pain
Stress
Inflammation
Omega-3 needs
Salt Sensitivity
Endurance
Power performance
Strength
Exercise recovery
Brain Fog
Female Fertility
Longevity
Addiction
Erectile Dysfunction
Male Infertility
MTHFR
Joint Inflammation
GERD
Ulcers
Sleep Apnea
Periodontitis
Varicose Veins
H. pylori
Liver Health
Canker Sores
Gallstones
Kidney Health
Gout
Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
Hemorrhoids
Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
Cannabis addiction
Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
Salicylate Sensitivity
Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps
SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
ARNTL
SNP Table
Summary
ARNTL (aka BMAL1) increases functionality in the circadian clock. It is associated with major depressive disorders, heightened responses to antidepressants, and is a key component in the functionality of the bodys circadian clock [R]. Disruptions in the circadian rhythms contribute to cardiovascular diseases, cancer, metabolic syndromes and aging.
ARNTL/BMAL1 increases muscle production and decreases fat cell creation.
ARNTL plays an important role in adult hippocampal neurogenesis. Increases the expression of enzymes that increase hormonal production, and also the genes involved in hair growth.
ARNTL/BMAL1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes, and obesity, and mutations in BMAL1 have been linked to infertility, gluconeogenesis and lipogenesis problems, and altered sleep patterns.
Protein names
GHR Function
More Information
One mice study indicated that deleting the gene causes a breakdown of the circadian clock, and development issues in the population [R].
Regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NRF2. Inhibits the mTORC1 signaling pathway; Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity and increases MAOA.
Mutations in the ARNTL gene cause disruptions in the resulting protein, which in turn cause incompatibility with other transcription factors, resulting in circadian arrhythmicity [R].
Variations of the ARNTL gene, as well as two other genes, CRY2 and PER2, have been found to be associated with unipolar depression, perhaps due to the disruption of the circadian clock as well as other psychotic disorders [R1, R2].
ARNTL increases vasopressin, an important hormone that regulates water retention the kidney [R1, R2].
Advanced information: ARNTL binds with CLOCK, which increases the expression of Period and Cryptochrome genes [R]. Cycles between promotion and repression of the regulatory loops take approximately 24 hours, representing one circadian clock [R]. Regulation of the ARNTL protein by competitive binding within the ARNTL promotor region; ARNTL/CLOCK bind to promoter regions EV-Erb and ROR/ß genes as well to begin production of their proteins, which in turn regulate ANTL by binding to the promoter region [R].
Lifestyle & Supplement Interactions
Reduced activity of the ARNTL gene causes the circadian rhythm to become disrupted, which leads to behavioral symptoms of depression (such as despair and hopelessness) in both humans and animals [R, R]. Therefore, you can potentially counteract your risk by increasing the activity of the ARNTL gene.
A good first step would be to avoid factors that may be further reducing your levels of ARNTL gene activity, such as being exposed to light during the evening and night time [R].
Exposure to cold can give your ARNTL levels a boost by activating a protein called PGC-1α, which increases the production of the ARNTL gene [R, R].
DHA -also stops palmitate induced decrease in BMAL1 (R).
Pathways:
Chronic activation of GSK3 impaired rhythmicity of BMAL1. Furthermore, chronic inhibition of GSK3 enhanced the amplitude and shortened the period of PER2 rhythms in SCN cultures [R].
Others:
Frequently Asked Questions
Unlock Personalized Results And So Much More!
Shipping Worldwide
30-Days Money-Back Guarantee*
US & EU Based Labs & Shipping
HSA & FSA Eligible
Essential Bundle
SelfDecode DNA Kit Included
+ Free Consultation
- 24/7 AI Health Coach
- Health Overview Report
- Diet & Nutrition Report
- 1 Health Topic of your choice (out of 35+ )
- Personalized Diet, Supplement & Lifestyle Recommendations
- Unlimited access to Labs Analyzer
HSA & FSA Eligible
Essential
Bundle
SelfDecode DNA Kit Included
+ Free Consultation
- Everything in Essential
- 1500+ Comprehensive DNA Health Reports
- All 35+ Health Topics
- 130+ Medical Reports
- 25+ Longevity Screener Risk Assessments
- Odds ratios to evaluate your risk for 25+ medical conditions
- 10-year risk scores to prioritize health conditions
- Lifetime risk scores to plan for long-term health
HSA & FSA Eligible
Ultimate Bundle
SelfDecode DNA Kit Included
+ Free Consultation
- Everything in Essential+
- 8 Pathway Reports
- Detox Pathways
- Methylation Pathway
- Histamine Pathway
- Dopamine & Norepinephrine Pathway
- Serotonin & Melatonin Pathway
- Male/Female Hormones Pathway
- Weight Control Pathway
- GABA & Glutamate Pathway
- Medication Check (PGx testing) for 50+ medications
- DNAmind PGx Report
- 40+ Family Planning (Carrier Status) Reports
- Ancestry Composition
- Deep Ancestry (Mitochondrial)
Limited Time Offer 25% Off
Not ready for a full bundle?
Individual DNA Reports
- HSA & FSA Eligible
* SelfDecode DNA kits are non-refundable. If you choose to cancel your plan within 30 days you will not be refunded the cost of the kit.
We will never share your data
We follow HIPAA and GDPR policies
We have World-Class Encryption & Security
Rated 4.7/5 from 750+ reviews
200,000+ users, 2,000+ doctors & 100+ businesses
SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.