inflammation & autoimmunity

allergies

TLR10

Can Antimicrobial Immunity Prevent Allergies? (TLR10)

Written by Aleksa Ristic, MS (Pharmacy) on October 21st, 2020

Can microbial exposure protect you from allergies? It depends on your genes! Read this post to discover the role of TLR10 in allergies and get gene-based recommendations (+bonus parent tips at the bottom).

Summary

The TLR10 gene helps make a crucial immune system receptor. TLR activation by microbes stimulates Th1 immunity and helps prevent allergies.

Specific gene variants reduce TLR10 activity and correlate with higher odds of allergic diseases.

This post reveals simple ways to reduce allergies by targeting TLR10 variants.

TLRs and Th1 Immunity in Allergy Prevention

TLR10 belongs to a group of genes encoding vital immune system receptors (toll-like receptors or TLRs). They recognize parts of different microbes, supporting their removal [R, R].

TLR receptor activation by pathogens stimulates different inflammatory cytokines that promote Th1 and suppress Th2 immunity. Allergies are Th2-dominant states, so adequate TLR activity is crucial for their prevention, especially during the immune system development [R, R, R].

The above pathways are central to the “hygiene hypothesis,” suggesting that the lack of microbial exposure in early childhood may contribute to allergic diseases [R, R].

The TLR10 gene helps make a crucial immune system receptor. TLR activation by microbes stimulates Th1 immunity and helps prevent allergies.

Your TLR10 Results for Allergies

SNP Table

variant	genotype	frequency	risk allele
rs5743618
rs17616434
rs2101521

Primary SNPs:

rs5743618 [R, R, R]:

‘A’ – associated with lower odds of allergic diseases
‘C’ – associated with relatively higher odds of allergic diseases

rs17616434 [R, R]:

‘C’ – associated with lower odds of allergic diseases
‘T’ – associated with relatively higher odds of allergic diseases

rs2101521 [R]:

‘A’ – associated with lower odds of allergic diseases
‘G’ – associated with relatively higher odds of allergic diseases

These variants are often inherited together, especially in European descendants. They belong to a group of TLR genes including TLR1, TLR6, and TLR10.

Protective alleles increase TLR activity and stimulate antimicrobial responses, shifting the immune system from Th2 towards Th1 [R].

Recommendations

Lifestyle

Allergy Immunotherapy

Allergy immunotherapy consists of administering a dilution of the allergen (such as pollen, dust mites, or dog dander) to help develop tolerance. Doctors use this treatment for allergic rhinitis, asthma, and conjunctivitis but not for food allergies [R, R, R, R, R].

Bee sting therapy is recommended as the first-line treatment to prevent severe allergic reactions in people allergic to the venom of bees and other insects of the same order (Hymenoptera) [R, R, R].

Immunotherapy does the same thing as TLR activation: it induces a shift from Th2 to Th1 immunity. New forms of immunotherapy directly targeting TLRs have yielded promising results, and more research is underway [R, R, R].

Immunotherapy may reduce allergic reactions by targeting your TLR10 variants.

Supplements

Probiotics

Different probiotic strains, such as L. acidophilus and L. paracasei, can enhance antimicrobial immunity through TLR activation [R, R, R].

Probiotic supplementation may improve the symptoms of:

Allergic rhinitis (L. acidophilus, L. paracasei, L. plantarum, L. casei) [R, R, R, R]
Pollen and dust mites allergy ( L. rhamnosus, L. johnsonii, C. butyricum) [R, R, R]
Asthma (L.salivarius, B. breve, C. butyricum) [R, R]
Milk and peanut allergies (L. rhamnosus, L. delbrueckii, L. fermentum [R, R, R, R, R]
Eczema (L. rhamnosus, L.reuteri, L. plantarum, L. paracasei, L. fermentum) [R, R, R, R]

Probiotic supplementation may boost TLR activity and help with different types of allergy.

*BONUS PARENT TIPS: Early childhood is a crucial period to “train” the immune system and achieve the right Th1/Th2 balance and TLR activity [R].

If you have children, make sure they spend some time in nature and allow them to get dirty—it may help prevent allergies! Children exposed to rural farming environments have lower odds of allergic diseases [R, R, R].

Breastfeeding is another way to stimulate immunity and TLR function in infants [R].

Aleksa Ristic

MS (Pharmacy)

Aleksa received his MS in Pharmacy from the University of Belgrade, his master thesis focusing on protein sources in plant-based diets.

Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. He found a way to merge his two biggest passions—writing and health—and use them for noble purposes. His mission is to bridge the gap between science and everyday life, helping readers improve their health and feel better.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

More inflammation & autoimmunity blogs

How to Combat Histamine Intolerance Through Genetics (DAO) Are You Genetically Vulnerable to High Brain Histamine, Migraines, or ADHD? (HNMT) How to Tell if You’re Lectin Sensitive Using Your Genetic Data (CNR1) Are You Sensitive to Lectins? (MTHFR) Fight Oxidative Stress, Inflammation, and Brain Fog (PARP1) Is This Gene Causing Your Autoimmune Problems? (PTPN22) Are You Genetically Susceptible to Post-Treatment Lyme? (ABCB1) A Key Genetic Player in Autoimmunity (HLA-B) Is This Inflammation Gene Reducing Your Intelligence? (TNFSF9) Can You Manage Allergies and Asthma by Balancing Methylation? (MTHFR)

More allergies blogs

Can You Manage Allergies and Asthma by Balancing Methylation? (MTHFR)

Content

Summary TLRs and Th1 Immunity in Allergy Prevention Your TLR10 Results for Allergies

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