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FOXO3

Can This Gene Influence Your Risk of Gut Inflammation (FOXO3)?

Written by Carlos Tello, PhD on September 1st, 2020

The FOXO3 gene encodes a protein that regulates the expression of other genes. By lowering the levels of inflammatory cytokines, it helps reduce gut inflammation. A variant with increased activity has been associated with milder symptoms of Crohn’s disease. Read on to find out.

Summary

The FOXO3 gene codes for a protein that regulates the expression of other genes.
Cytokines can cause inflammation in the gut. FOXO3 reduces the severity of gut inflammation by lowering cytokine levels.
A FOXO3 variant increasing its production is associated with milder symptoms of Crohn’s disease.
Specific lifestyle, dietary, and supplement choices may increase FOXO3 activity and reduce gut inflammation.

The FOXO3 Gene & Gut Inflammation

The FOXO3 gene encodes a protein that regulates the expression of other genes and has been implicated in immune function, DNA repair, and tumor suppression [R, R, R].
Cytokines are proteins that stimulate the immune response and the development of T cells in response to harmful microbes [R, R].
FOXO3 activity reduces the levels of the inflammatory cytokines TNF -alpha, IL-1β, IL-6, and IL-8, while increasing the anti-inflammatory cytokine IL-10 [R, R].
People with ulcerative colitis have lower FOXO3 levels [R]
In mice, the lack of FOXO3 causes more severe gut inflammation and higher rates of inflammation-related colon cancer [R, R, R, R].
Read this post to learn more about the FOXO3 gene and its association with longevity.

Your FOXO3 Results for Gut Inflammation

SNP Summary and Table

FOXO3 rs12212067

‘T’ = Normal severity of Crohn’s disease
‘C’ = Milder severity of Crohn’s disease

SNP Table

variant	genotype	frequency	risk allele
rs12212067

Recommendations

Lifestyle

Exercise

Moderate physical activity changes the composition of the gut flora by increasing beneficial species [R, R].
Physical exercise helps prevent IBD, but some people with active disease may be unable to adjust their physical activity. Staying physically fit by exercising regularly is essential as a means of prevention [R, R, R].
Interestingly, exercise increases FOXO3 levels [R, R].

Physical activity improves the gut microbiota, helps prevent IBD, and increases FOXO3 activity. Moderate, regular exercise may produce the best results.

Diet

Avoiding Food Triggers & Including Beneficial Foods

In a study of people with Crohn’s disease, carriers of the ‘G’ variant often experienced worsened symptoms after eating wasabi, tomatoes (especially raw), mustard, and ginger [R].
In the same study, people with this variant often benefited from eating sweet potatoes, Jerusalem artichokes, green beans, beefsteak, and peas [R].

In carriers of the ‘G’ variant, food such as wasabi, tomatoes, mustard, and ginger may worsen Crohn’s disease symptoms while sweet potatoes, Jerusalem artichokes, green beans, beefsteak, and peas may be beneficial.

Supplements

Curcumin

Curcumin is the active component of the Indian spice turmeric.

Curcumin inhibits multiple proteins involved in the immune response [R].
Preliminary research in animals and cells suggests that curcumin shows promise in the treatment of IBD [R].
In the above-described study on people with Crohn’s disease, carriers of the ‘G’ variant often reported benefits from eating curry dishes with turmeric [R].

Curcumin may help with IBD by reducing inflammation. Carriers of the ‘G’ variant suffering from Crohn’s disease may especially benefit from curcumin-rich curry dishes.

Carlos Tello

PhD

Carlos received his PhD and MS from the Universidad de Sevilla.

Carlos spent 8 years in the laboratory investigating mineral transport in plants. He then started working as a freelancer, mainly in science writing, editing, and consulting. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and lay audiences. He strongly believes that scientific literacy is crucial to maintaining a healthy lifestyle and avoiding falling for scams.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

More gut health blogs

Could This Gene Be Linked To Gut Inflammation? (ATG16L1) Could This Gene Play A Role In Inflammatory Bowel Disease? (STAT3) How Do Your Genes Respond to Dietary Fat? (TCF7L2) Do Your Genes Favor the Mediterranean Diet? (TCF7L2) How Does this Serotonin Receptor Affect Gut Inflammation? (HTR3E) The Impact of a Serotonin Receptor on IBS-D (HTR3A) How Can Neurotrophins Affect Gut Inflammation? (BDNF) Could Your IBS Symptoms Be Caused by an Enzyme Deficiency? (SI) What is the Connection Between β-Klotho and Gut Inflammation? (KLB) Can This Gene Worsen Gut Inflammation? (NOS2)

Content

Summary The FOXO3 Gene & Gut Inflammation Your FOXO3 Results for Gut Inflammation

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Can This Gene Influence Your Risk of Gut Inflammation (FOXO3)?

Summary

The FOXO3 Gene & Gut Inflammation

Your FOXO3 Results for Gut Inflammation

SNP Summary and Table

SNP Table

Recommendations

Lifestyle

Exercise

Diet

Avoiding Food Triggers & Including Beneficial Foods

Supplements

Curcumin

Disclaimer

More gut health blogs

Content

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Limited time offer 25% off

Ultimate Bundle

Policies

About

Navigation

Health reports